Irisin immunohistochemistry in gastrointestinal system cancers

被引：88

作者：

Aydin, S. ^{[1
,5
]}

Kuloglu, T. ^{[2
]}

Ozercan, M. R. ^{[3
]}

Albayrak, S. ^{[4
]}

Aydin, S. ^{[1
,5
]}

Bakal, U. ^{[6
]}

Yilmaz, M. ^{[1
]}

Kalayci, M. ^{[7
]}

Yardim, M. ^{[1
]}

Sarac, M. ^{[6
]}

Kazez, A. ^{[6
]}

Kocdor, H. ^{[8
]}

Kanat, B. ^{[9
]}

Ozercan, I. H. ^{[3
]}

Gonen, M. ^{[10
]}

Bilgen, M. ^{[11
]}

Balgetir, F. ^{[10
]}

机构：

[1] Firat Univ, Sch Med, Dept Med Biochem, Firat Hormones Res Grp, TR-23119 Elazig, Turkey

[2] Firat Univ, Sch Med, Dept Histol & Embryol, TR-23169 Elazig, Turkey

[3] Firat Univ, Sch Med, Dept Pathol, TR-23169 Elazig, Turkey

[4] Elazig Educ & Res Hosp, Dept Neurosurg, Elazig, Turkey

[5] Firat Univ, Sch Med, Dept Anat, TR-23169 Elazig, Turkey

[6] Firat Univ, Sch Med, Dept Pediat Surg, TR-23169 Elazig, Turkey

[7] Elazig Educ & Res Hosp, Med Biochem Lab, Elazig, Turkey

[8] Dokuz Eylul Univ, Sch Med, Dept Med Biochem, Izmir, Turkey

[9] Elazig Educ & Res Hosp, Dept Gen Surg, Elazig, Turkey

[10] Firat Univ, Sch Med, Dept Neurol, TR-23169 Elazig, Turkey

[11] Univ Oslo, Sch Med, Oslo, Norway

来源：

BIOTECHNIC & HISTOCHEMISTRY | 2016年 / 91卷 / 04期

关键词：

cancer; gastrointestinal system; immunohistochemistry; irisin; WARBURG; CELL; SERUM; METABOLISM; ADROPIN; MYOKINE; TUMORS; COLON; FAT;

D O I：

10.3109/10520295.2015.1136988

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cancer is the leading cause of morbidity and mortality worldwide. Some studies have shown that high heat kills cancer cells. Irisin is a protein involved in heat production by converting white into brown adipose tissue, but there is no information about how its expression changes in cancerous tissues. We used irisin antibody immunohistochemistry to investigate changes in irisin expression in gastrointestinal cancers compared to normal tissues. Irisin was found in human brain neuroglial cells, esophageal epithelial cells, esophageal epidermoid carcinoma, esophageal adenocarcinoma and neuroendocrine esophageal carcinoma, gastric glands, gastric adenosquamous carcinoma, gastric neuroendocrine carcinoma, gastric signet ring cell carcinoma, neutrophils in vascular tissues, intestinal glands of colon, colon adenocarcinoma, mucinous colon adenocarcinoma, hepatocytes, hepatocellular carcinoma, islets of Langerhans, exocrine pancreas, acinar cells and interlobular and interlobular ducts of normal pancreas, pancreatic ductal adenocarcinoma, and intra- and interlobular ducts of cancerous pancreatic tissue. Histoscores (area x intensity) indicated that irisin was increased significantly in gastrointestinal cancer tissues, except liver cancers. Our findings suggest that the relation of irisin to cancer warrants further investigation.

引用

页码：242 / 250

页数：9

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