Ten-year trends in epidemiology and outcomes of pediatric kidney replacement therapy in Europe: data from the ESPN/ERA-EDTA Registry

被引：42

作者：

Bonthuis, Marjolein ^{[1
]}

Vidal, Enrico ^{[2
]}

Bjerre, Anna ^{[3
]}

Aydog, Ozlem ^{[4
]}

Baiko, Sergey ^{[5
]}

Garneata, Liliana ^{[6
]}

Guzzo, Isabella ^{[7
]}

Heaf, James G. ^{[8
]}

Jahnukainen, Timo ^{[9
,10
]}

Lilien, Marc ^{[11
]}

Mallett, Tamara ^{[12
,13
]}

Mirescu, Gabriel ^{[14
,15
]}

Mochanova, Elena A. ^{[16
]}

Nuesken, Eva ^{[17
,18
]}

Rascher, Katherine ^{[18
,19
]}

Roussinov, Dimitar ^{[20
]}

Szczepanska, Maria ^{[21
]}

Tsimaratos, Michel ^{[22
]}

Varvara, Askiti ^{[23
]}

Verrina, Enrico ^{[24
]}

Veselinovic, Bojana ^{[25
]}

Jager, Kitty J. ^{[1
]}

Harambat, Jerome ^{[26
]}

机构：

[1] Univ Amsterdam, Amsterdam UMC, ESPN ERA EDTA Registry, Dept Med Informat,Amsterdam Publ Hlth Res Inst, Meibergdreef 9, Amsterdam, Netherlands

[2] Univ Udine, Div Pediat, Dept Med, Udine, Italy

[3] Oslo Univ Hosp, Div Pediat & Adolescent Med, Oslo, Norway

[4] 19 Mayis Univ, Dept Pediat Nephrol, Sch Med, Samsun, Turkey

[5] Belarusian State Med Univ, Dept Pediat, Minsk, BELARUS

[6] Carol Davila Univ Med & Pharm, Dept Internal Med & Nephrol, Dr Carol Davila Teaching Hosp Nephrol, Bucharest, Romania

[7] Bambino Gesu Pediat Hosp, Inst Sci Res, Pediat Subspecialties Dept, Nephrol & Dialysis Unit, Rome, Italy

[8] Zealand Univ Hosp, Dept Med, Roskilde, Denmark

[9] Univ Helsinki, New Childrens Hosp, Dept Pediat Nephrol & Transplantat, Helsinki, Finland

[10] Helsinki Univ Hosp, Helsinki, Finland

[11] Univ Med Ctr, Wilhelmina Childrens Hosp, Utrecht, Netherlands

[12] Royal Belfast Hosp Sick Children, Dept Paediat Nephrol, Belfast, Antrim, North Ireland

[13] Royal Bristol Hosp Children, Dept Paediat Nephrol, Bristol, Avon, England

[14] Carol Davila Univ Med & Pharm, Dept Nephrol & Internal Med, Bucharest, Romania

[15] Dr Carol Davila Teaching Hosp Nephrol, Dept Nephrol, Bucharest, Romania

[16] Russian Childrens Fed Clin Hosp Pirogov Russian N, Dept Kidney Transplantat, Moscow, Russia

[17] Univ Cologne, Fac Med, Dept Pediat, Pediat Nephrol, Cologne, Germany

[18] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[19] Univ Cologne, Fac Med, Dept Med 2, QiN Grp, Cologne, Germany

[20] Med Univ Sofia, Dept Pediat, Nephrol & Hemodialysis Clin, SBAL Pediat Dis, Sofia 1606, Bulgaria

[21] Med Univ Silesia, Fac Med Sci Zabrze, Dept Pediat, Katowice, Poland

[22] AP HP, Dept Multidisciplinary Pediat, Pediat Nephrol Unit, Marseille, France

[23] Kyriakou Childrens Hosp, Nephrol Unit, Athens, Greece

[24] IRCCS Giannina Gaslini, Dept Pediat, Dialysis Unit, Genoa, Italy

[25] Univ Childrens Hosp, Dept Nephrol, Belgrade, Serbia

[26] Univ Bordeaux, Bordeaux Univ Hosp, Dept Pediat, Bordeaux Populat Hlth Res Ctr,UMR 1219, Bordeaux, France

来源：

PEDIATRIC NEPHROLOGY | 2021年 / 36卷 / 08期

关键词：

Dialysis; Peritoneal dialysis; Hemodialysis; Transplantation; Pediatrics; Epidemiology; ESPN; ERA-EDTA Registry;

D O I：

10.1007/s00467-021-04928-w

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background For 10 consecutive years, the ESPN/ERA-EDTA Registry has included data on children with stage 5 chronic kidney disease (CKD 5) receiving kidney replacement therapy (KRT) in Europe. We examined trends in incidence and prevalence of KRT and patient survival. Methods We included all children aged <15 years starting KRT 2007-2016 in 22 European countries participating in the ESPN/ERA-EDTA Registry since 2007. General population statistics were derived from Eurostat. Incidence and prevalence were expressed per million age-related population (pmarp) and time trends studied with JoinPoint regression. We analyzed survival trends using Cox regression. Results Incidence of children commencing KRT <15 years remained stable over the study period, varying between 5.5 and 6.6 pmarp. Incidence by treatment modality was unchanged over time: 2.0 for hemodialysis (HD) and peritoneal dialysis (PD) and 1.0 for transplantation. Prevalence increased in all age categories and overall rose 2% annually from 26.4 pmarp in 2007 to 32.1 pmarp in 2016. Kidney transplantation prevalence increased 5.1% annually 2007-2009, followed by 1.5% increase/year until 2016. Prevalence of PD steadily increased 1.4% per year over the entire period, and HD prevalence started increasing 6.1% per year from 2011 onwards. Five-year unadjusted patient survival on KRT was around 94% and similar for those initiating KRT 2007-2009 or 2010-2012 (adjusted HR: 0.98, 95% CI:0.71-1.35). Conclusions We found a stable incidence and increasing prevalence of European children on KRT 2007-2016. Five-year patient survival was good and was unchanged over time. These data can inform patients and healthcare providers and aid health policy makers on future resource planning of pediatric KRT in Europe.

引用

页码：2337 / 2348

页数：12

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