Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

被引：127

作者：

Sharma, S.

Chopra, K.

Kulkarni, S. K.

Agrewala, J. N.

机构：

[1] Inst Microbial Technol, Immunol Lab, Chandigarh 160036, India

[2] Panjab Univ, Div Pharmacol, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2007年 / 147卷 / 01期

关键词：

CD28; CD40; CD80; CTLA-4; curcumin; IL-10; resveratrol; T-CELLS; IMMUNOSUPPRESSION; DIFERULOYLMETHANE; PROLIFERATION; AUTOIMMUNITY; SECRETION; APOPTOSIS; THERAPY; TARGETS; CANCER;

D O I：

10.1111/j.1365-2249.2006.03257.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.

引用

页码：155 / 163

页数：9

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