Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

被引：127
作者：
Sharma, S.
Chopra, K.
Kulkarni, S. K.
Agrewala, J. N.
机构：
[1] Inst Microbial Technol, Immunol Lab, Chandigarh 160036, India
[2] Panjab Univ, Div Pharmacol, Univ Inst Pharmaceut Sci, Chandigarh 160014, India
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2007年 / 147卷 / 01期
关键词：
CD28; CD40; CD80; CTLA-4; curcumin; IL-10; resveratrol; T-CELLS; IMMUNOSUPPRESSION; DIFERULOYLMETHANE; PROLIFERATION; AUTOIMMUNITY; SECRETION; APOPTOSIS; THERAPY; TARGETS; CANCER;
D O I：
10.1111/j.1365-2249.2006.03257.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
引用
收藏
页码：155 / 163
页数：9
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