Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice

被引：14

作者：

Akiho, Mai ^{[1
]}

Nakashima, Hiroyuki ^{[1
]}

Sakata, Munehiro ^{[2
]}

Yamasa, Yuka ^{[2
]}

Yamaguchi, Akihiko ^{[3
]}

Sakuma, Kunihiro ^{[1
]}

机构：

[1] Toyohashi Univ Technol, Res Ctr Phys Fitness Sports & Hlth, Toyohashi, Aichi 4418580, Japan

[2] Kyoto Prefectural Univ Med, Dept Legal Med, Kamigyo Ku, Kyoto 6028566, Japan

[3] Hlth Sci Univ Hokkaido, Sch Dent, Kanazawa Ku, Ishikari, Hokkaido 06102, Japan

来源：

LIFE SCIENCES | 2010年 / 86卷 / 1-2期

关键词：

Notch-1; Myogenin; Satellite cell; Skeletal muscle; Hypertrophy; SATELLITE CELL ACTIVATION; SKELETAL-MUSCLE; PROGENITOR CELLS; RBP-J; MYOGENIC DIFFERENTIATION; POSTNATAL MYOGENESIS; FIBER HYPERTROPHY; STEM-CELLS; PATHWAY; REGENERATION;

D O I：

10.1016/j.lfs.2009.11.011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice. Main methods: We performed immunofluorescence of both Notch-1 and the Notch-l-linking molecules. Key findings: immunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2-6. We observed clear co-localization between Notch-1 and myogenin (4.9 +/- 1.3%) in the hypertrophied muscle at 4 days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1 +/- 1.2%). Significance: Notch-1 may play an important role in the maintenance of quiescent satellite cells. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：59 / 65

页数：7

共 39 条

[1] Expression of connexins during differentiation and regeneration of skeletal muscle:: functional relevance of connexin43 [J].

Araya, R ;

Eckardt, D ;

Maxeiner, S ;

Krüger, O ;

Theis, M ;

Willecke, K ;

Sáez, JC .

JOURNAL OF CELL SCIENCE, 2005, 118 (01) :27-37

[2]

ARMSTRONG RB, 1979, J APPL PHYSIOL, V81, P2509

[3] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[4] Notch signaling in leukemia [J].

Aster, Jon C. ;

Pear, Warren S. ;

Blacklow, Stephen C. .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2008, 3 :587-613

[5] Impaired expression of Notch signaling genes in aged human skeletal muscle [J].

Carey, Kate A. ;

Farnfield, Michelle M. ;

Tarquinio, Sarah D. ;

Cameron-Smith, David .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2007, 62 (01) :9-17

[6] Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells [J].

Carlson, Morgan E. ;

Hsu, Michael ;

Conboy, Irina M. .

NATURE, 2008, 454 (7203) :528-U9

[7] Regulating the Notch pathway in embryonic, adult and old stem cells [J].

Carlson, Morgan E. ;

Conboy, Irina M. .

CURRENT OPINION IN PHARMACOLOGY, 2007, 7 (03) :303-309

[8] The regulation of notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis [J].

Conboy, IM ;

Rando, TA .

DEVELOPMENTAL CELL, 2002, 3 (03) :397-409

[9] Rejuvenation of aged progenitor cells by exposure to a young systemic environment [J].

Conboy, IM ;

Conboy, MJ ;

Wagers, AJ ;

Girma, ER ;

Weissman, IL ;

Rando, TA .

NATURE, 2005, 433 (7027) :760-764

[10] Notch-mediated restoration of regenerative potential to aged muscle [J].

Conboy, IM ;

Conboy, MJ ;

Smythe, GM ;

Rando, TA .

SCIENCE, 2003, 302 (5650) :1575-1577

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