Cordycepin diminishes thymic stromal lymphopoietin-induced interleukin-13 production

被引：11

作者：

Yoou, Myoung-schook ^{[1
]}

Yoon, Kyoung Wan ^{[2
]}

Choi, Youngjin ^{[3
]}

Kim, Hyung-Min ^{[1
]}

Jeong, Hyun-Ja ^{[3
]}

机构：

[1] Kyung Hee Univ, Coll Korean Med, Dept Pharmacol, 26 Kyungheedae Ro, Seoul 02447, South Korea

[2] Hoseo Univ, Dept Biotechnol, 20,Hoseo Ro 79beon Gil, Asan 31499, Chungcheongnam, South Korea

[3] Hoseo Univ, Dept Food Sci & Technol, 20,Hoseo Ro 79beon Gil, Asan 31499, Chungcheongnam, South Korea

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2017年 / 802卷

关键词：

Cordycepin; Thymic stromal lymphopoietin; Interleukin-13; Signal transducer and activator of transcription; 6; Murine double minute 2; MAST-CELL ACTIVATION; ATOPIC-DERMATITIS; SIGNALING PATHWAYS; TSLP; MDM2; APOPTOSIS; PROLIFERATION; INFLAMMATION; EXPRESSION; OPPORTUNITIES;

D O I：

10.1016/j.ejphar.2017.02.033

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atopic dermatitis (AD) is known to aggravate by thymic stromal lymphopoietin (TSLP) and TSLP is also known to up-regulate mast cell proliferation via production of interleukin (IL)-13. Thus, we investigated whether cordycepin could regulate mast cell proliferation induced by TSLP in human mast cell line, HMC-1 cell. Cordycepin significantly diminished the production and mRNA of IL-13 through the down-regulation of phosphorylated-signal transducer and activation of transcription 6 in the TSLP-stimulated HMC-1 cells. Cordycepin also significantly diminished the cell proliferation via down-regulating MDM2 and Bc12 levels and up-regulating p53, caspase-3, and cleaved poly ADP-ribose polymerase levels in the TSLP-stimulated HMC-1 cells. Moreover, cordycepin significantly diminished the production of IL-6, tumor necrosis factor-alpha, and IL-1 beta in the TSLP-stimulated HMC-1 cells. In conclusion, our study shows that cordycepin has potential effect for the treatment of allergic inflammatory diseases through the blockade of IL-13 and MDM2 exacerbated by TSLP.

引用

页码：1 / 6

页数：6

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