Killing of E-coli cells by E group nuclease colicins

被引:74
作者
James, R [1 ]
Penfold, CN
Moore, GR
Kleanthous, C
机构
[1] Univ Nottingham Hosp, Div Microbiol & Infect Dis, Sch Clin Lab Sci, Nottingham NG7 2UH, England
[2] Univ E Anglia, Sch Chem Sci, Norwich NR4 7TJ, Norfolk, England
[3] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
colicin; H-N-H endonuclease; BtuB receptor; translocation; DNase;
D O I
10.1016/S0300-9084(02)01450-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The process by which the endonuclease domain of colicin E9 is translocated across the outer membrane, the periplasmic space and the cytoplasmic membrane to reach the cytoplasm of E. coli cells, resulting in DNA degradation and cell death, is a unique event in prokaryotic biology. Although considerable information is known about the role of the BtuB outer membrane receptor, as well as the mostly periplasmic Tol proteins that are essential for the translocation process, the precise nature of the interactions between colicin E9 and these proteins remains to be elucidated. In this review, we consider our current understanding of the key events in this process, concentrating on recent findings concerning receptor-binding, translocation and the mechanism of cytotoxicity. (C) 2002 Societe francaise de biochimie et biologic moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:381 / 389
页数:9
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