Highly Sensitive Metamaterial Biosensor for Cancer Early Detection

被引：93
作者：
Azab, Mohammad Y. [1 ]
Hameed, Mohamed Farhat O. [1 ,2 ]
Nasr, Abed M. [1 ]
Obayya, S. S. A. [2 ]
机构：
[1] Mansoura Univ, Fac Engn, Math & Engn Phys Dept, Mansoura 35516, Egypt
[2] Zewail City Sci & Technol, Ctr Photon & Smart Mat, Giza 12578, Egypt
来源：
IEEE SENSORS JOURNAL | 2021年 / 21卷 / 06期
关键词：
Metamaterials; Absorption; Sensors; Sensitivity; Biosensors; Cancer; Resonant frequency; Metamaterial; absorber; biosensor; cancer detection; and terahertz; REFRACTIVE-INDEX; SOLAR-CELL; ABSORBER; SENSOR;
D O I：
10.1109/JSEN.2021.3051075
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A novel design of metamaterial biosensor for cancer early detection is proposed and analyzed. The suggested structure is based on two loops of hexagonal gold layers on a polyamide substrate. High field confinement is obtained in the sensing region with high absorption of 0.999 and high quality factor of 11.33 at f 3.15 THz. The resonance frequency is sensitive to the sample refractive index variation. Therefore, high average sensitivity of 1649.8 GHz/RIU is achieved for cancer early detection through basal cell, breast cell, bervical cell, jurkat, MCF-7, and PC12. Further, high linear performance is obtained with good robustness against fabrication imperfection. The analysis is carried out using full vectorial finite element method.
引用
收藏
页码：7748 / 7755
页数：8
相关论文
共 30 条
[1]   Photonic Crystal Fiber-Based Refractive Index Sensor for Early Detection of Cancer [J].
Ayyanar, N. ;
Raja, G. Thavasi ;
Sharma, Mohit ;
Kumar, D. Sriram .
IEEE SENSORS JOURNAL, 2018, 18 (17) :7093-7099
[2]   Metamaterials Application in Sensing [J].
Chen, Tao ;
Li, Suyan ;
Sun, Hui .
SENSORS, 2012, 12 (03) :2742-2765
[3]   Ultrasensitive terahertz metamaterial sensor based on spoof surface plasmon [J].
Chen, Xu ;
Fan, Wenhui .
SCIENTIFIC REPORTS, 2017, 7
[4]   Full-field optical coherence microscopy for identifying live cancer cells by quantitative measurement of refractive index distribution [J].
Choi, Woo June ;
Jeon, Do In ;
Ahn, Sang-Gun ;
Yoon, Jung-Hoon ;
Kim, Sungho ;
Lee, Byeong Ha .
OPTICS EXPRESS, 2010, 18 (22) :23285-23295
[5]  
COMSOL AB, Comsol multiphysics
[6]   A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage [J].
Geng, Zhaoxin ;
Zhang, Xiong ;
Fan, Zhiyuan ;
Lv, Xiaoqing ;
Chen, Hongda .
SCIENTIFIC REPORTS, 2017, 7
[7]  
Hameed M., 2019, Computational photonic sensors, DOI 10.1007/978-3-319-76556-3
[8]   Ultra-thin metamaterial for perfect and quasi-omnidirectional sound absorption [J].
Jimenez, N. ;
Huang, W. ;
Romero-Garcia, V. ;
Pagneux, V. ;
Groby, J. -P. .
APPLIED PHYSICS LETTERS, 2016, 109 (12)
[9]   Dual-band refractometric terahertz biosensing with intense wave-matter-overlap microfluidic channel [J].
Lan, Feng ;
Luo, Feng ;
Mazumder, Pinaki ;
Yang, Ziqiang ;
Meng, Lin ;
Bao, Zhengqiang ;
Zhou, Jun ;
Zhang, Yaxin ;
Liang, Shixiong ;
Shi, Zongjun ;
Khan, Abdur Rauf ;
Zhang, Ziqi ;
Wang, Luyang ;
Yin, Jing ;
Zeng, Hongxin .
BIOMEDICAL OPTICS EXPRESS, 2019, 10 (08) :3789-3799
[10]   Perfect metamaterial absorber [J].
Landy, N. I. ;
Sajuyigbe, S. ;
Mock, J. J. ;
Smith, D. R. ;
Padilla, W. J. .
PHYSICAL REVIEW LETTERS, 2008, 100 (20)
123