Synthetic studies towards (-)-deserpidine: Total synthesis of the stereoisomer and derivative of (-)-deserpidine

被引：3
作者：
Wu, Pingzhou [1 ,2 ]
Zhou, Qilong [3 ,4 ]
Liu, Xiao-Yu [1 ,2 ]
Xue, Fei [1 ,2 ]
Qin, Yong [1 ,2 ]
机构：
[1] Sichuan Univ, Sichuan Engn Lab Plant Sourced Drug, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst,Educ, Chengdu 610041, Peoples R China
[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China
[3] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China
[4] Chongqing Univ, Innovat Drug Res Ctr, Chongqing 401331, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Yohimbine alkaloids; Deserpidine; Photoredox catalytic radical cascade reaction; Total synthesis; STEREOSPECIFIC SYNTHESIS; DESERPIDINE; RESERPINE;
D O I：
10.1016/j.cclet.2020.02.009
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The asymmetric synthesis of 16,17,20-epi-deserpidine and a derivative of (-)-deserpidine has been achieved. Key features in the assembly of the pentacyclic framework include a visible-light photocatalytic intra-/inter-/intramolecular radical cascade reaction to construct the tetracyclic ABCD ring system in one-pot and an intramolecularaldol reaction to forge the cyclohexane E ring. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：401 / 404
页数：4
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