Importance of nonpharmacological factors in nicotine self-administration

被引：138
作者：
Caggiula, AR
Donny, EC
Chaudhri, N
Perkins, KA
Evans-Martin, FF
Sved, AF
机构：
[1] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA
[3] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15260 USA
[4] Johns Hopkins Sch Med, Dept Psychiat, Behav Pharmacol Res Unit, Baltimore, MD USA
来源：
PHYSIOLOGY & BEHAVIOR | 2002年 / 77卷 / 4-5期
关键词：
nonpharmacological factors; nicotine; self-administration;
D O I：
10.1016/S0031-9384(02)00918-6
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
There is mounting evidence that nonpharmacological factors critically modulate the effects of several drugs of abuse both in humans and experimental animals. This paper reviews research from this laboratory on one factor that influences the degree to which nicotine is self-administered: environmental stimuli that form the context within which nicotine is taken. The results suggest that the direct, pharmacological actions of nicotine are necessary but not sufficient to explain either the high rates of self-administration exhibited by laboratory animals or cigarette smoking by humans, and that future investigations on the neurophysiological effects of nicotine that underlie smoking behavior must take into account the environmental context within which the behavior occurs. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：683 / 687
页数：5
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