Highly efficient synthesis of α-aminophosphonates catalyzed by hafnium(IV) chloride

被引：40
作者：
Li, Xiao-Chuan [1 ]
Gong, Shan-Shan [1 ]
Zeng, De-Yun [1 ]
You, Yue-Hai [1 ]
Sun, Qi [1 ]
机构：
[1] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, 605 Fenglin Ave, Nanchang 330013, Jiangxi, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 16期
基金：
中国国家自然科学基金;
关键词：
Aminophosphonate; Hafnium chloride; Catalysis; Aldehyde; Phosphite; MECHANISM-BASED INACTIVATION; KABACHNIK-FIELDS REACTION; STATE ANALOG INHIBITORS; AMINO PHOSPHONATES; PHOSPHINIC ACID; ALDEHYDES; POTENT; DERIVATIVES; SYNTHETASE; DESIGN;
D O I：
10.1016/j.tetlet.2016.03.033
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient one-pot method for the synthesis of a variety of alpha-aminophosphonates via the one-pot three-component reaction of aldehyde, amine, and phosphite has been developed using only 2 mol % HfCl4 as the catalyst. The NMR evidence strongly indicated the catalytic roles of Hf(IV) on the activation of aldehyde, phosphite, and imine intermediate. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1782 / 1785
页数：4
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