Site-Selective Defluorinative sp3 C-H Alkylation of Secondary Amides

被引：144
|
作者：
Yue, Wen-Jun [1 ,2 ]
Day, Craig S. [1 ,2 ]
Martin, Ruben [1 ,3 ]
机构：
[1] Inst Chem Res Catalonia ICIQ, Barcelona Inst Sci & Technol, Tarragona 43007, Spain
[2] Univ Rovira & Virgili, Dept Quim Analit & Quim Organ, Tarragona 43007, Spain
[3] ICREA, Barcelona 08010, Spain
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2021年 / 143卷 / 17期
基金：
欧盟地平线“2020”;
关键词：
BOND ACTIVATION; FUNCTIONALIZATION;
D O I：
10.1021/jacs.1c03126
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A site-selective defluorinative sp(3) C-H alkylation of secondary amides that rapidly and reliably incorporates gemdifluoroalkene motifs into previously unfunctionalized sp(3) sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.
引用
收藏
页码：6395 / 6400
页数：6
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