Extremely rapid spread of human immunodeficiency virus type 1 BF recombinants in Argentina

被引：34
作者：
Aulicino, Paula C.
Holmes, Edward C.
Rocco, Carlos
Mangano, Andrea
Sen, Luisa
机构：
[1] Hosp Pediat JP Garrahan, CONICET, Lab Biol Celular & Retrovirus, RA-1245 Buenos Aires, DF, Argentina
[2] Penn State Univ, Dept Biol, Ctr Infect Dis Dynam, University Pk, PA 16802 USA
[3] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA
来源：
JOURNAL OF VIROLOGY | 2007年 / 81卷 / 01期
关键词：
D O I：
10.1128/JVI.01403-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The epidemic of human immunodeficiency virus type 1 (HIV-1) in Argentina is distinctive in that many infections are caused by subtype BF recombinant viruses. To determine their demographic history, we estimated the evolutionary rate, mode of population growth, and age of genetic diversity among 40 BF vpu sequences. This revealed one of the highest substitution rates reported for HIV-1, at 10.793 x 10(-3) substitutions per site per year, and a very rapid rate of population growth, with an initial mean epidemic doubling time of 3.72 months. This rapid population growth is compatible with an elevated fitness for subtype BF compared to that for "pure" B and F viruses.
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收藏
页码：427 / 429
页数：3
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