Role of Myo-Inositol by Magnetic Resonance Spectroscopy in Early Diagnosis of Alzheimer's Disease in APP/PS1 Transgenic Mice

被引:57
作者
Chen, Shuang-Qing [1 ]
Wang, Pei-Jun [1 ]
Ten, Gao-Jun [2 ,3 ]
Zhan, Wei [1 ]
Li, Ming-Hua [1 ]
Zang, Feng-Chao [3 ]
机构
[1] Tongji Univ, Tongji Hosp, Dept Radiol, Shanghai 200065, Peoples R China
[2] Southeast Univ, Dept Radiol, Nanjing, Peoples R China
[3] Southeast Univ, Zhongda Hosp, Mol Imaging Lab, Nanjing, Peoples R China
关键词
Alzheimer's disease; Magnetic resonance spectroscopy; Astrocyte; Myo-inositol; MILD COGNITIVE IMPAIRMENT; MR SPECTROSCOPY; AMYLOID-BETA; H-1; MRS; N-ACETYLASPARTATE; MOUSE MODELS; BRAIN; DEMENTIA; CORTEX; ABNORMALITIES;
D O I
10.1159/000261646
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background/Aims: To explore the potential value of myoinositol (mIns), which is regarded as a biomarker for early diagnosis of Alzheimer's disease, in APP/PS1 transgenic (tg) mice detected by H-1-MRS. Methods: H-1-MRS was performed in 30 APP/PS1 tg mice and 20 wild-type (wt) littermates at 3, 5 and 8 months of age. Areas under the peak of N-acetylaspartate (NAA), mIns and creatine (Cr) in the frontal cortex and hippocampus were measured, and the NAA/Cr and mIns/Cr ratios were analyzed quantitatively. Results: Compared with the wt mice, the mIns/Cr ratio of the 3-month-old tg mice was significantly higher ( p < 0.05), and pathology showed activation and proliferation of astrocytes in the frontal cortex and hippocampus. The concentration of NAA was significantly lower at 8 and 8 months of age ( p < 0.05). According to the threshold of mIns/Cr that was adopted to separate the tg from the wt mice, the rate of correct predictions was 82, 94 and 95%, respectively, for 3, 5 and 8 months. Conclusion: Of the early AD metabolites as detected by H-1-MRS, mIns is the most valuable marker for assessment of AD. Quantitative analysis of mIns may provide important clues for early diagnosis of AD. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:558 / 566
页数:9
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