Addiction related alteration in resting-state brain connectivity

被引：265

作者：

Ma, Ning ^{[1
,2
]}

Liu, Ying ^{[3
]}

Li, Nan ^{[1
,2
]}

Wang, Chang-Xin ^{[3
]}

Zhang, Hao ^{[6
]}

Jiang, Xiao-Feng ^{[4
,5
]}

Xu, Hu-Sheng ^{[1
,2
]}

Fu, Xian-Ming ^{[4
,5
]}

Hu, Xiaoping ^{[7
]}

Zhang, Da-Ren ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Hefei Natl Lab Phys Sci Microscale, Div Biox Interdisciplinary Sci, Hefei 230027, Anhui, Peoples R China

[2] Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol & Biophys, Hefei 230027, Anhui, Peoples R China

[3] Anhui Prov Hosp, Dept MRI, Hefei 230001, Anhui, Peoples R China

[4] Anhui Prov Hosp, Dept Neurosurg, Hefei 230001, Anhui, Peoples R China

[5] Anhui Prov Inst Stereotact Neurosurg, Hefei 230001, Anhui, Peoples R China

[6] Anhui Detoxificat & Rehabil Ctr, Hefei 230601, Anhui, Peoples R China

[7] Emory Univ, Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA

来源：

NEUROIMAGE | 2010年 / 49卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HUMAN ORBITOFRONTAL CORTEX; FUNCTIONAL CONNECTIVITY; DRUG-ADDICTION; CINGULATE CORTEX; DECISION-MAKING; COCAINE; REWARD; HEROIN; FLUCTUATIONS; ASSOCIATION;

D O I：

10.1016/j.neuroimage.2009.08.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is widely accepted that addictive drug use is related to abnormal functional organization in the user's brain. The present study aimed to identify this type of abnormality within the brain networks implicated in addiction by resting-state functional connectivity measured with functional magnetic resonance imaging (fMRI). With fMRI data acquired during resting state from 14 chronic heroin users (12 of whom were being treated with methadone) and 13 non-addicted controls, we investigated the addiction related alteration in functional connectivity between the regions in the circuits implicated in addiction with seed-based correlation analysis. Compared with controls, chronic heroin users showed increased functional connectivity between nucleus accumbens and ventral/rostral anterior cingulate cortex (ACC), between nucleus accumbens and orbital frontal cortex (OFC), and between amygdala and OFC and reduced functional connectivity between prefrontal cortex and OFC and between prefrontal cortex and ACC. These observations of altered resting-state functional connectivity Suggested abnormal functional organization in the addicted brain and may provide additional evidence Supporting the theory of addiction that emphasizes enhanced salience value of a drug and its related cues but weakened cognitive control in the addictive state. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：738 / 744

页数：7

共 60 条

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