Solid phase synthesis of 2-aminobutadienes using a piperazine linker

被引：38

作者：

Hird, NW ^{[1
]}

Irie, K ^{[1
]}

Nagai, K ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,YODOGAWA KU,OSAKA 532,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(97)01633-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of resin-bound 4-substituted-2-aminobutadienes have been synthesised via Wittig reaction with polymer supported 2-(N-piperazino)prop-1-enyl-1-triphenylphosphonium bromide. The use of piperazine provides a readily cleavable enamine linker for attachment of ketones that is compatible with anion chemistry. (C) 1997 Elsevier Science Ltd.

引用

页码：7111 / 7114

页数：4

共 6 条

[1] A SIMPLE AND EFFICIENT SYNTHESIS OF 2-AMINO-1,3-BUTADIENES FROM BETA-ENAMINO PHOSPHONIUM SALTS [J].

BARLUENGA, J ;

MERINO, I ;

PALACIOS, F .

TETRAHEDRON LETTERS, 1990, 31 (46) :6713-6716

[2] Synthesis of a highly functionalized rigid template by solid phase azomethine ylide cycloaddition [J].

Bicknell, AJ ;

Hird, NW .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (20) :2441-2444

[3] Synthesis of ketones and aldehydes via reactions of Weinreb-type amides on solid support [J].

Dinh, TQ ;

Armstrong, RW .

TETRAHEDRON LETTERS, 1996, 37 (08) :1161-1164

[4]

ENDERS D, 1994, SYNTHESIS-STUTTGART, P66

[5] Solid-phase organic reactions: A review of the recent literature [J].

Hermkens, PHH ;

Ottenheijm, HCJ ;

Rees, D .

TETRAHEDRON, 1996, 52 (13) :4527-4554

[6] CHIRAL 2-AMINO-1,3-BUTADIENES - NEW REAGENTS FOR ASYMMETRIC CYCLOADDITIONS [J].

KROHN, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1993, 32 (11) :1582-1584

← 1 →