Downregulation of HOXC6 in Serous Ovarian Cancer

被引：21
|
作者：
Tait, David L. [1 ]
Bahrani-Mostafavi, Zahra [2 ]
Vestal, C. Greer [3 ]
Richardson, Christine [3 ]
Mostafavi, M. Taghi [2 ]
机构：
[1] Carolinas Med Ctr, Levine Canc Inst, Div Gynecol Oncol, Charlotte, NC 28203 USA
[2] UNC Charlotte, Coll Comp & Informat, Charlotte, NC USA
[3] UNC Charlotte, Dept Biol Sci, Charlotte, NC USA
来源：
CANCER INVESTIGATION | 2015年 / 33卷 / 07期
关键词：
Biomarker discovery; Homeobox genes; HOXC6; Serous ovarian cancer; C6; GENE-PRODUCTS; HOMEOBOX B3; IMMUNOCYTOCHEMICAL DETECTION; EXPRESSION PROFILES; ESTROGEN-RECEPTOR; CELL-LINES; B4; DIFFERENTIATION; CARCINOMA;
D O I：
10.3109/07357907.2015.1041641
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Homeobox (HOX) genes encode transcription factors critical to morphogenesis and cell differentiation. Although dysregulation of several HOX genes in ovarian cancer has been reported, little is known about HOXC6 expression in epithelial ovarian cancer. In this report, analysis of laser capture microdissected samples determined HOXC6 expression patterns in normal versus malignant serous ovarian carcinoma tissues. HOXC6 protein was quantified by ELISA in parallel serum samples and further validated in a larger cohort of serum samples collected from women with and without serous ovarian carcinoma. These data demonstrate significant downregulation of HOXC6 in serous ovarian cancer.
引用
收藏
页码：303 / 311
页数：9
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