Antrocamphin A, an Anti-inflammatory Principal from the Fruiting Body of Taiwanofungus camphoratus, and Its Mechanisms

被引：65

作者：

Hsieh, Yu-Hsin ^{[2
,4
]}

Chu, Fang-Hua ^{[5
]}

Wang, Ya-Shin ^{[3
]}

Chien, Shih-Chang ^{[6
]}

Chang, Shang-Tzen ^{[5
]}

Shaw, Jei-Fu ^{[5
,7
]}

Chen, Chieh-Yin ^{[8
]}

Hsiao, Wen-Wei ^{[8
]}

Kuo, Yueh-Hsiung ^{[1
]}

Wang, Sheng-Yang ^{[3
]}

机构：

[1] China Med Univ, Grad Inst Chinese Pharmaceut Sci, Taichung, Taiwan

[2] Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 40227, Taiwan

[3] Natl Chung Hsing Univ, Dept Forestry, Taichung 40227, Taiwan

[4] Acad Sinica, Taiwan Int Grad Program, Mol & Biol Agr Sci Program, Taipei 115, Taiwan

[5] Natl Taiwan Univ, Sch Forestry & Resource Conservat, Taipei 10764, Taiwan

[6] China Med Univ, Sch Chinese Med Resources, Taichung, Taiwan

[7] Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, Taichung 40227, Taiwan

[8] Natl Taiwan Univ, Coll Bioresources & Agr, Taipei, Taiwan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2010年 / 58卷 / 05期

关键词：

Taiwanofungus camphoratus; anti-inflammation; antrocamphin A; NO; PGE2; NF-kappa B; NF-KAPPA-B; ANTRODIA-CAMPHORATA; COX-2; EXTRACTS; MYCELIA;

D O I：

10.1021/jf903638p

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The fungus Taiwanofungus camphoratus is commonly used for medicinal purposes in Taiwan. It is used as a detoxicant for food poisoning and considered to be a precious folk medicine for hepatoprotection and anti-inflammation. In this study, a lipopolysacca ride (LPS)-challenged ICR mouse acute inflammation model and a LPS-induced macrophage model were used to evaluate the anti-inflammatory activity of T. camphoratus. Ethanol extract of T. camphoratus significantly inhibited expression of NOS and COX-2 in the liver of LPS-challenged acute inflammatory mice. The ethyl acetate fraction and its isolated compound, antrocamphin A, significantly suppressed nitrite/nitrate concentration in LPS-challenged RAW 264.7 cells. Antrocamphin A showed potent anti-inflammatory activity by suppressing pro-inflammatory molecule release via the down-regulation of NOS and COX-2 expression through the NF-kappa B pathway. This study, therefore, first demonstrates the bioactive compound of T. camphoratus and illustrates the mechanism by which it confers its anti-inflammatory activity.

引用

页码：3153 / 3158

页数：6

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