Interleukin-1 Gene-511 CT Polymorphism and the Risk of Alzheimer's Disease in a Polish Population

被引：14

作者：

Klimkowicz-Mrowiec, A. ^{[1
,2
]}

Marona, M. ^{[1
]}

Wolkow, P. ^{[3
]}

Maruszak, A. ^{[4
]}

Styczynska, M. ^{[4
]}

Barcikowska, M. ^{[4
]}

Zekanowski, C. ^{[4
]}

Szczudlik, A. ^{[1
]}

Slowik, A. ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Neurol, Sch Med, PL-31503 Krakow, Poland

[2] Jagiellonian Univ, Sch Med, Dept Neurol, Univ Hosp, PL-31503 Krakow, Poland

[3] Jagiellonian Univ, Sch Med, Dept Pharmacol, PL-31503 Krakow, Poland

[4] Polish Acad Sci, Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 28卷 / 05期

关键词：

Alzheimer's disease; Interleukin-1; Polymorphism; Risk factor; Polish population; ASSOCIATION; ONSET; IL-1-ALPHA; IL-1-BETA; DEMENTIA; BETA;

D O I：

10.1159/000259460

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Interleukin-1 is a potent proinflammatory cytokine involved in the pathophysiology of Alzheimer's disease (AD). We genotyped IL-1 beta (-511 C/T) and the apolipoprotein E (APOE) common polymorphisms in a large case-controlled study in a Polish population. We included 332 patients with late-onset AD and 220 controls without any neurological deficit, cognitive complaints and history of neurological diseases, aged >= 65 years. The distribution of the IL-1 beta (-511 C/T) genotypes was similar to that in the controls (AD: C/C = 45.8%, C/T = 44.6%, T/T = 9.6% vs. controls: C/C = 53.9%, C/T = 38.3%, T/T = 7.3%, p > 0.05). Our study confirms previous reports that APOE epsilon 4 is strongly related to the risk of AD (odds ratio = 6.60, 95% confidence interval 4.19-10.41). APOE status did not affect the distribution of the studied IL-1 beta polymorphism. The IL-1 beta (-511 C/T) polymorphism is not a risk factor for late-onset AD in a Polish population. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：461 / 464

页数：4

共 29 条

[1] Evidence for glial-mediated inflammation in aged APPSW transgenic mice [J].

Benzing, WC ;

Wujek, JR ;

Ward, EK ;

Shaffer, D ;

Ashe, KH ;

Younkin, SG ;

Brunden, KR .

NEUROBIOLOGY OF AGING, 1999, 20 (06) :581-589

[2] Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain [J].

Deniz-Naranjo, M. C. ;

Munoz-Fernandez, C. ;

Alemany-Rodriguez, M. J. ;

Perez-Vieitez, M. C. ;

Aladro-Benito, Y. ;

Irurita-Latasa, J. ;

Sanchez-Garcia, F. .

EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 (10) :1080-1084

[3] Association between the interleukin-1β polymorphisms and Alzheimer's disease: A systematic review and meta-analysis [J].

Di Bona, Danilo ;

Plaia, Antonella ;

Vasto, Sonya ;

Cavallone, Luca ;

Lescai, Francesco ;

Franceschi, Claudio ;

Licastro, Federico ;

Colonna-Romano, Giuseppina ;

Lio, Domenico ;

Candore, Giuseppina ;

Caruso, Calogero .

BRAIN RESEARCH REVIEWS, 2008, 59 (01) :155-163

[4] Biologic basis for interleukin-1 in disease [J].

Dinarello, CA .

BLOOD, 1996, 87 (06) :2095-2147

[5] Association of an interleukin 1α polymorphism with Alzheimer's disease [J].

Du, Y ;

Dodel, RC ;

Eastwood, BJ ;

Bales, KR ;

Gao, F ;

Lohmüller, F ;

Müller, U ;

Kurz, A ;

Zimmer, R ;

Evans, RM ;

Hake, A ;

Gasser, T ;

Oertel, WH ;

Griffin, WST ;

Paul, SM ;

Farlow, MR .

NEUROLOGY, 2000, 55 (04) :480-483

[6]

FOLSTEIN MF, 1975, J PSYCHIATR RES, V12, P198

[7]

GRIFFIN WST, 1989, P NATL ACAD SCI USA, V86, P7611

[8]

Grimaldi LME, 2000, ANN NEUROL, V47, P361, DOI 10.1002/1531-8249(200003)47:3<361::AID-ANA12>3.0.CO

[9]

2-N

[10] Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia [J].

Hedley, R ;

Hallmayer, J ;

Groth, DM ;

Brooks, WS ;

Gandy, SE ;

Martins, RN .

ANNALS OF NEUROLOGY, 2002, 51 (06) :795-797

← 1 2 3 →