Heart Failure in the Era of Precision Medicine: A Scientific Statement From the American Heart Association

被引：46
作者：
Cresci, Sharon [1 ]
Pereira, Naveen L. [2 ]
Ahmad, Ferhaan [3 ]
Byku, Mirnela [4 ]
de las Fuentes, Lisa [1 ]
Lanfear, David E. [5 ]
Reilly, Carolyn M. [7 ]
Owens, Anjali T. [6 ]
Wolf, Matthew J. [8 ]
机构：
[1] Washington Univ, Sch Med, St Louis, MO 63110 USA
[2] Mayo Clin, Rochester, MN USA
[3] Univ Iowa, Carver Coll Med, Iowa City, IA 52242 USA
[4] Univ N Carolina, Chapel Hill, NC 27515 USA
[5] Henry Ford Hosp, Detroit, MI 48202 USA
[6] Univ Penn, Ctr Inherited Cardiovasc Dis, Perelman Sch Med, Philadelphia, PA 19104 USA
[7] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA
[8] Univ Virginia, Charlottesville, VA 22903 USA
来源：
CIRCULATION-GENOMIC AND PRECISION MEDICINE | 2019年 / 12卷 / 10期
基金：
美国国家卫生研究院;
关键词：
AHA Scientific Statements; early diagnosis; heart failure; precision medicine; preventive medicine; GENOME-WIDE ASSOCIATION; REDUCED EJECTION FRACTION; LONG NONCODING RNA; CARDIAC RESYNCHRONIZATION THERAPY; TRIMETHYLAMINE-N-OXIDE; PROTEIN-KINASE-D; NATRIURETIC-PEPTIDE; DILATED CARDIOMYOPATHY; PROGNOSTIC VALUE; HYPERTROPHIC CARDIOMYOPATHY;
D O I：
10.1161/HCG.0000000000000058
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
One of 5 people will develop heart failure over his or her lifetime. Early diagnosis and better understanding of the pathophysiology of this disease are critical to optimal treatment. The "omics"-genomics, pharmacogenomics, epigenomics, proteomics, metabolomics, and microbiomics- of heart failure represent rapidly expanding fields of science that have, to date, not been integrated into a single body of work. The goals of this statement are to provide a comprehensive overview of the current state of these omics as they relate to the development and progression of heart failure and to consider the current and potential future applications of these data for precision medicine with respect to prevention, diagnosis, and therapy.
引用
收藏
页码：458 / 485
页数：28
相关论文
共 257 条
[1]   Psychological Issues in Genetic Testing for Inherited Cardiovascular Diseases [J].
Aatre, Rajani D. ;
Day, Sharlene M. .
CIRCULATION-CARDIOVASCULAR GENETICS, 2011, 4 (01) :81-90
[2]  
Ackerman MJ, 2011, HEART RHYTHM, V8, P1308, DOI [10.1016/j.hrthm.2011.05.020, 10.1093/europace/eur245]
[3]   A method and server for predicting damaging missense mutations [J].
Adzhubei, Ivan A. ;
Schmidt, Steffen ;
Peshkin, Leonid ;
Ramensky, Vasily E. ;
Gerasimova, Anna ;
Bork, Peer ;
Kondrashov, Alexey S. ;
Sunyaev, Shamil R. .
NATURE METHODS, 2010, 7 (04) :248-249
[4]   Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases [J].
Agerholm-Larsen, L ;
Raben, A ;
Haulrik, N ;
Hansen, AS ;
Manders, M ;
Astrup, A .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2000, 54 (04) :288-297
[5]   Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support [J].
Ahmad, Tariq ;
Kelly, Jacob P. ;
McGarrah, Robert W. ;
Hellkamp, Anne S. ;
Fiuzat, Mona ;
Testani, Jeffrey M. ;
Wang, Teresa S. ;
Verma, Amanda ;
Samsky, Marc D. ;
Donahue, Mark P. ;
Ilkayeva, Olga R. ;
Bowles, Dawn E. ;
Patel, Chetan B. ;
Milano, Carmelo A. ;
Rogers, Joseph G. ;
Felker, G. Michael ;
O'Connor, Christopher M. ;
Shah, Svati H. ;
Kraus, William E. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (03) :291-299
[6]   Galectin-3 in Heart Failure: More Answers or More Questions? [J].
Ahmad, Tariq ;
Felker, G. Michael .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2012, 1 (05)
[7]   Meta-Analysis of Soluble Suppression of Tumorigenicity-2 and Prognosis in Acute Heart Failure [J].
Aimo, Alberto ;
Vergaro, Giuseppe ;
Ripoli, Andrea ;
Bayes-Genis, Antoni ;
Figal, Domingo A. Pascual ;
de Boer, Rudolf A. ;
Lassus, Johan ;
Mebazaa, Alexandre ;
Gayat, Etienne ;
Breidthardt, Tobias ;
Sabti, Zaid ;
Mueller, Christian ;
Brunner-La Rocca, Hans-Peter ;
Tang, W. H. Wilson ;
Grodin, Justin L. ;
Zhang, Yuhui ;
Bettencourt, Paulo ;
Maisel, Alan S. ;
Passino, Claudio ;
Januzzi, James L. ;
Emdin, Michele .
JACC-HEART FAILURE, 2017, 5 (04) :287-296
[8]   Prognostic Value of Soluble Suppression of Tumorigenicity-2 in Chronic Heart Failure A Meta-Analysis [J].
Aimo, Alberto ;
Vergaro, Giuseppe ;
Passino, Claudio ;
Ripoli, Andrea ;
Ky, Bonnie ;
Miller, Wayne L. ;
Bayes-Genis, Antoni ;
Anand, Inder ;
Januzzi, James L. ;
Emdin, Michele .
JACC-HEART FAILURE, 2017, 5 (04) :280-286
[9]   Inflammatory biomarkers as predictors of heart failure in women without obstructive coronary artery disease: A report from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) [J].
AlBadri, Ahmed ;
Lai, Kha ;
Wei, Janet ;
Landes, Sofy ;
Mehta, Puja K. ;
Li, Quanlin ;
Johnson, Delia ;
Reis, Steven E. ;
Kelsey, Sheryl F. ;
Bittner, Vera ;
Sopko, George ;
Shaw, Leslee J. ;
Pepine, Carl J. ;
Merzl, C. Noel Bairey .
PLOS ONE, 2017, 12 (05)
[10]  
Alfares AA, 2015, GENET MED, V17, P880, DOI [10.1038/gim.2014.205, 10.1038/gim.2015.16]
12345678910