Brain Metabolic Correlates of Persistent Olfactory Dysfunction after SARS-Cov2 Infection

被引：37
作者：
Donegani, Maria Isabella [1 ,2 ]
Miceli, Alberto [1 ,2 ]
Pardini, Matteo [1 ,3 ]
Bauckneht, Matteo [1 ,2 ]
Chiola, Silvia [4 ,5 ]
Pennone, Michele [1 ,2 ]
Marini, Cecilia [1 ,6 ]
Massa, Federico [1 ,3 ]
Raffa, Stefano [1 ,4 ]
Ferrarazzo, Giulia [1 ,4 ]
Arnaldi, Dario [1 ,4 ]
Sambuceti, Gianmario [1 ,4 ]
Nobili, Flavio [1 ,3 ]
Morbelli, Silvia [1 ,2 ]
机构：
[1] IRCCS Osped Policlin San Martino, I-16131 Genoa, Italy
[2] Univ Genoa, Dept Hlth Sci, Nucl Med Unit, I-516126 Genoa, Italy
[3] Univ Genoa, Dept Neurosci DINOGMI, I-516126 Genoa, Italy
[4] Humanitas Clin & Res Ctr IRCCS, Via Manzoni 56, I-20089 Milan, Italy
[5] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20090 Milan, Italy
[6] CNR, Inst Mol Bioimaging & Physiol IBFM, I-20090 Milan, Italy
来源：
BIOMEDICINES | 2021年 / 9卷 / 03期
关键词：
18F-FDG PET; anosmia; COVID-19; SARS-CoV-2; olfactory dysfunction; COGNITIVE IMPAIRMENT; ANOSMIA; CORTEX; PET;
D O I：
10.3390/biomedicines9030287
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [F-18]-FDG PET, including a dedicated brain acquisition at our institution between May and December 2020 following their recovery after SARS-Cov2 infection. Fourteen of these patients presented isolated persistent hyposmia (smell diskettes olfaction test was used). A voxel-wise analysis (using Statistical Parametric Mapping software version 8 (SPM8)) was performed to identify brain regions of relative hypometabolism in patients with hyposmia with respect to controls. Structural connectivity of these regions was assessed (BCB toolkit). Relative hypometabolism was demonstrated in bilateral parahippocampal and fusiform gyri and in left insula in patients with respect to controls. Structural connectivity maps highlighted the involvement of bilateral longitudinal fasciculi. This study provides evidence of cortical hypometabolism in patients with isolated persistent hyposmia after SARS-Cov2 infection. [F-18]-FDG PET may play a role in the identification of long-term brain functional sequelae of COVID-19.
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页数：11
相关论文
共 37 条
[21]   Olfactory Bulb MRI and Paranasal Sinus CT Findings in Persistent COVID-19 Anosmia [J].
Kandemirli, Sedat Giray ;
Altundag, Aytug ;
Yildirim, Duzgun ;
Sanli, Deniz Esin Tekcan ;
Saatci, Ozlem .
ACADEMIC RADIOLOGY, 2021, 28 (01) :28-35
[22]   18FDG PET/CT Scan Reveals Hypoactive Orbitofrontal Cortex in Anosmia of COVID-19 [J].
Karimi-Galougahi, Mahboobeh ;
Yousefi-Koma, Abbas ;
Bakhshayeshkaram, Mehrdad ;
Raad, Nasim ;
Haseli, Sara .
ACADEMIC RADIOLOGY, 2020, 27 (07) :1042-1043
[23]   The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study [J].
Kas, Aurelie ;
Soret, Marine ;
Pyatigoskaya, Nadya ;
Habert, Marie-Odile ;
Hesters, Adele ;
Le Guennec, Loic ;
Paccoud, Olivier ;
Bombois, Stephanie ;
Delorme, Cecile .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2021, 48 (08) :2543-2557
[24]   Bilateral transient olfactory bulb edema during COVID-19-related anosmia [J].
Laurendon, Thomas ;
Radulesco, Thomas ;
Mugnier, Justine ;
Gerault, Melanie ;
Chagnaud, Christophe ;
El Ahmadi, Ahmed-Ali ;
Varoquaux, Arthur .
NEUROLOGY, 2020, 95 (05) :224-225
[25]   Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study [J].
Lechien, Jerome R. ;
Chiesa-Estomba, Carlos M. ;
De Siati, Daniele R. ;
Horoi, Mihaela ;
Le Bon, Serge D. ;
Rodriguez, Alexandra ;
Dequanter, Didier ;
Blecic, Serge ;
El Afia, Fahd ;
Distinguin, Lea ;
Chekkoury-Idrissi, Younes ;
Hans, Stephane ;
Lopez Delgado, Irene ;
Calvo-Henriquez, Christian ;
Lavigne, Philippe ;
Falanga, Chiara ;
Barillari, Maria Rosaria ;
Cammaroto, Giovanni ;
Khalife, Mohamad ;
Leich, Pierre ;
Souchay, Christel ;
Rossi, Camelia ;
Journe, Fabrice ;
Hsieh, Julien ;
Edjlali, Myriam ;
Carlier, Robert ;
Ris, Laurence ;
Lovato, Andrea ;
De Filippis, Cosimo ;
Coppee, Frederique ;
Fakhry, Nicolas ;
Ayad, Tareck ;
Saussez, Sven .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2020, 277 (08) :2251-2261
[26]   Astrocytes couple synaptic activity to glucose utilization in the brain [J].
Magistretti, PJ ;
Pellerin, L .
NEWS IN PHYSIOLOGICAL SCIENCES, 1999, 14 :177-182
[27]   The role of anterior prefrontal cortex in prospective memory: an exploratory FDG-PET study in early Alzheimer's disease [J].
Massa, Federico ;
Grisanti, Stefano ;
Brugnolo, Andrea ;
Doglione, Elisa ;
Orso, Beatrice ;
Morbelli, Silvia ;
Bauckneht, Matteo ;
Origone, Paola ;
Filippi, Laura ;
Arnaldi, Dario ;
De Carli, Fabrizio ;
Pardini, Matteo ;
Pagani, Marco ;
Nobili, Flavio ;
Girtler, Nicola .
NEUROBIOLOGY OF AGING, 2020, 96 :117-127
[28]   COVID-19 and anosmia: A review based on up-to-date knowledge [J].
Meng, Xiangming ;
Deng, Yanzhong ;
Dai, Zhiyong ;
Meng, Zhisheng .
AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2020, 41 (05)
[29]   COVID-19 and the brain: impact on nuclear medicine in neurology [J].
Morbelli, Silvia ;
Ekmekcioglu, Ozgul ;
Barthel, Henryk ;
Albert, Nathalie L. ;
Boellaard, Ronald ;
Cecchin, Diego ;
Guedj, Eric ;
Lammertsma, Adriaan A. ;
Law, Ian ;
Penuelas, Ivan ;
Semah, Franck ;
Traub-Weidinger, Tatjana ;
van de Giessen, Elsmarieke ;
Varrone, Andrea ;
Garibotto, Valentina .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 47 (11) :2487-2492
[30]   18F-FDG PET diagnostic and prognostic patterns do not overlap in Alzheimer's disease (AD) patients at the mild cognitive impairment (MCI) stage [J].
Morbelli, Silvia ;
Bauckneht, Matteo ;
Arnaldi, Dario ;
Picco, Agnese ;
Pardini, Matteo ;
Brugnolo, Andrea ;
Buschiazzo, Ambra ;
Pagani, Marco ;
Girtler, Nicola ;
Nieri, Alberto ;
Chincarini, Andrea ;
De Carli, Fabrizio ;
Sambuceti, Gianmario ;
Nobili, Flavio .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 (12) :2073-2083
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