Brain Metabolic Correlates of Persistent Olfactory Dysfunction after SARS-Cov2 Infection

被引：37

作者：

Donegani, Maria Isabella ^{[1
,2
]}

Miceli, Alberto ^{[1
,2
]}

Pardini, Matteo ^{[1
,3
]}

Bauckneht, Matteo ^{[1
,2
]}

Chiola, Silvia ^{[4
,5
]}

Pennone, Michele ^{[1
,2
]}

Marini, Cecilia ^{[1
,6
]}

Massa, Federico ^{[1
,3
]}

Raffa, Stefano ^{[1
,4
]}

Ferrarazzo, Giulia ^{[1
,4
]}

Arnaldi, Dario ^{[1
,4
]}

Sambuceti, Gianmario ^{[1
,4
]}

Nobili, Flavio ^{[1
,3
]}

Morbelli, Silvia ^{[1
,2
]}

机构：

[1] IRCCS Osped Policlin San Martino, I-16131 Genoa, Italy

[2] Univ Genoa, Dept Hlth Sci, Nucl Med Unit, I-516126 Genoa, Italy

[3] Univ Genoa, Dept Neurosci DINOGMI, I-516126 Genoa, Italy

[4] Humanitas Clin & Res Ctr IRCCS, Via Manzoni 56, I-20089 Milan, Italy

[5] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20090 Milan, Italy

[6] CNR, Inst Mol Bioimaging & Physiol IBFM, I-20090 Milan, Italy

来源：

BIOMEDICINES | 2021年 / 9卷 / 03期

关键词：

18F-FDG PET; anosmia; COVID-19; SARS-CoV-2; olfactory dysfunction; COGNITIVE IMPAIRMENT; ANOSMIA; CORTEX; PET;

D O I：

10.3390/biomedicines9030287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [F-18]-FDG PET, including a dedicated brain acquisition at our institution between May and December 2020 following their recovery after SARS-Cov2 infection. Fourteen of these patients presented isolated persistent hyposmia (smell diskettes olfaction test was used). A voxel-wise analysis (using Statistical Parametric Mapping software version 8 (SPM8)) was performed to identify brain regions of relative hypometabolism in patients with hyposmia with respect to controls. Structural connectivity of these regions was assessed (BCB toolkit). Relative hypometabolism was demonstrated in bilateral parahippocampal and fusiform gyri and in left insula in patients with respect to controls. Structural connectivity maps highlighted the involvement of bilateral longitudinal fasciculi. This study provides evidence of cortical hypometabolism in patients with isolated persistent hyposmia after SARS-Cov2 infection. [F-18]-FDG PET may play a role in the identification of long-term brain functional sequelae of COVID-19.

引用

页数：11

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