Clinical lessons learned from the first leg of the CAR T cell journey

被引：438

作者：

Majzner, Robbie G. ^{[1
,2
]}

Mackall, Crystal L. ^{[1
,2
,3
]}

机构：

[1] Dept Pediat, Stanford, CA 94305 USA

[2] Stanford Canc Inst, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

来源：

NATURE MEDICINE | 2019年 / 25卷 / 09期

关键词：

CHIMERIC ANTIGEN RECEPTORS; ACUTE LYMPHOBLASTIC-LEUKEMIA; B-CELL; ANTITUMOR-ACTIVITY; TUMOR-ANTIGEN; ADOPTIVE IMMUNOTHERAPY; 4-1BB COSTIMULATION; HODGKIN-LYMPHOMA; SURFACE-ANTIGEN; THERAPY;

D O I：

10.1038/s41591-019-0564-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chimeric antigen receptor (CAR) T cell therapy for B cell malignancies has surpassed expectations, driving an ever-expanding number of clinical trials and the first US Food and Drug Administration approvals of cell therapies for the treatment of cancer. This experience has illuminated some generalizable requirements for CAR T cell efficacy as well as the interplay between disease biology and clinical outcomes. Major CAR intrinsic variables affecting T cell behavior have been defined, and mechanisms of tumor resistance are increasingly understood. Here, we review the clinical experience with CAR T cells amassed to date, including but not limited to B cell malignancies, emphasizing factors associated with efficacy, resistance and major barriers to success. We also discuss how these insights are driving next-generation clinical trials, including those in solid tumors.

引用

页码：1341 / 1355

页数：15

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