Three new taxoids from the seeds of Japanese yew, Taxus cuspidata

被引：21

作者：

Shi, QW

Oritani, T

Zhao, D

Murakami, R

Oritani, T

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Div Life Sci, Lab Appl Bioorgan Chem,Aoba Ku, Sendai, Miyagi 9818555, Japan

[2] Hebei Med Univ, Fac Pharmaceut Sci, Dept Chem Med Nat Prod, Shijiazhuang, Peoples R China

[3] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo, Japan

[4] Toyama Prefectural Univ, Jr Coll, Toyama, Japan

来源：

PLANTA MEDICA | 2000年 / 66卷 / 03期

关键词：

D O I：

10.1055/s-2000-8565

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five taxane diterpenoids were isolated from the seeds of the Japanese yew, Taxus cuspidata Sieb, et Zucc. The structures were established as 2 alpha, 7 beta, 13 alpha-triacetoxy-5 alpha-(3'-dimethylamino-3'-phenyl)-propionyloxy-2(3-->20)-aboe- taxa-9,10-dione (1) and 2 alpha, 7 beta, 9 alpha, 10 beta-tetraacetoxy-5 alpha-[(2R,3S),N,N-dimethyl-3-phenylisoseryloxy]-taxa-4(20),11-dien-13-one (2), 2 alpha, 9 alpha, 10 beta-triacetoxy-5 alpha-cinnamoxy-taxa-4(20),11-diene-13 alpha-ol (3), taxezopidine] (4), and taxuspine D (5) on the basis of 1D, 2D NMR, and MS spectral analysis. Compounds 1, 2, and 3 are new compounds.

引用

页码：294 / 299

页数：6

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