Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed?

被引：41
作者：
Vallely, Andrew
Vallely, Lisa
Changalucha, John
Greenwood, Brian
Chandramohan, Daniel
机构：
[1] Natl Inst Med Res, Mwanza Ctr, Mwanza, Tanzania
[2] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England
来源：
MALARIA JOURNAL | 2007年 / 6卷 / 1期
关键词：
D O I：
10.1186/1475-2875-6-16
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials.
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页数：13
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