Local dynamics of pharmaceutical powder fluidization using high speed long distance microscopy and particle image velocimetry

被引:6
作者
Elserfy, K. [1 ]
Cheng, S. [1 ]
Chan, H-K. [2 ]
Kourmatzis, A. [3 ]
机构
[1] Macquarie Univ, Sch Engn, N Ryde, NSW 2109, Australia
[2] Univ Sydney, Sch Pharm, Adv Drug Delivery Grp, Sydney, NSW 2006, Australia
[3] Univ Sydney, Sch Aerosp Mech & Mechatron Engn, Sydney, NSW 2006, Australia
基金
澳大利亚研究理事会;
关键词
Two-phase flow; Dry powder inhalers; Lactose carriers; Pharmaceutical carriers; Advanced imaging techniques;
D O I
10.1016/j.expthermflusci.2021.110367
中图分类号
O414.1 [热力学];
学科分类号
摘要
The local dynamics of fluidized pharmaceutical carrier powders in a turbulent channel flow was studied using particle image velocimetry (PIV) and High-speed, long-distance microscopy (HS-LDM). Four different lactose powders which have been used as a drug carrier in dry powder inhalers were used in this study. These powders have median powder particle diameters ranging between 61 and 121 mu m. Air flow velocities ranging between 13.3 m/s and 66.7 m/s were examined. In addition, the effect of grid blockage ratio (ranging from-25% to similar to 40% of the area of channel cross-section) was also investigated. Results show that the high-speed, long-distance microscopy (HS-LDM) technique was able to capture the mean velocity of the particles, and the results corresponded well with the PIV measurements. Results from the high-speed, long-distance microscopy (HS-LDM) method also demonstrate that the span of particle velocity closely follows that of the particle size distribution both for cohesive and non-cohesive powders. This study contributes towards an improved understanding of pharmaceutical carrier dynamics in turbulent channel flows and demonstrates how advanced image processing can be used to capture local particle dynamics.
引用
收藏
页数:15
相关论文
共 26 条
[11]   Effects of Turbulence, Evaporation and Heat Release on the Dispersion of Droplets in Dilute Spray Jets and Flames [J].
Kourmatzis, A. ;
O'Loughlin, W. ;
Masri, A. R. .
FLOW TURBULENCE AND COMBUSTION, 2013, 91 (02) :405-427
[12]   A two-angle far-field microscope imaging technique for spray flows [J].
Kourmatzis, Agisilaos ;
Pham, Phuong X. ;
Masri, Assaad R. .
MEASUREMENT SCIENCE AND TECHNOLOGY, 2017, 28 (03)
[13]   Characterization of atomization and combustion in moderately dense turbulent spray flames [J].
Kourmatzis, Agissilaos ;
Pham, Phuong X. ;
Masri, Assaad R. .
COMBUSTION AND FLAME, 2015, 162 (04) :978-996
[14]   Turbulent spray flames of intermediate density: Stability and near-field structure [J].
Lowe, Albyn ;
Kourmatzis, Agisilaos ;
Masri, Assaad R. .
COMBUSTION AND FLAME, 2017, 176 :511-520
[15]   Fluidisation characteristics of lactose powders in simple turbulent channel flows [J].
Mahmoudi, S. ;
Elserfy, K. ;
Cheng, S. ;
Chan, H-K ;
Hebbink, G. ;
Kourmatzis, A. .
EXPERIMENTAL THERMAL AND FLUID SCIENCE, 2019, 103 :201-213
[16]   Experimental investigation of design parameters on dry powder inhaler performance [J].
Nguyen Thi Quynh Ngoc ;
Chang, Lusi ;
Jia, Xinli ;
Lau, Raymond .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 457 (01) :92-100
[17]   Optical diagnostics study of air flow and powder fluidisation in Nexthaler®-Part I: Studies with lactose placebo formulation [J].
Pasquali, I. ;
Merusi, C. ;
Brambilla, G. ;
Long, E. J. ;
Hargrave, G. K. ;
Versteeg, H. K. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 496 (02) :780-791
[18]   Influence of physical properties of carrier on the performance of dry powder inhalers [J].
Peng, Tingting ;
Lin, Shiqi ;
Niu, Boyi ;
Wang, Xinyi ;
Huang, Ying ;
Zhang, Xuejuan ;
Li, Ge ;
Pan, Xin ;
Wu, Chuanbin .
ACTA PHARMACEUTICA SINICA B, 2016, 6 (04) :308-318
[19]  
Pope S. B., 2001, TURBULENT FLOWS
[20]   The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations [J].
Shur, Jagdeep ;
Harris, Haggis ;
Jones, Matthew D. ;
Kaerger, J. Sebastian ;
Price, Robert .
PHARMACEUTICAL RESEARCH, 2008, 25 (07) :1931-1940