Mature biofilms of Enterococcus faecalis and Enterococcus faecium are highly resistant to antibiotics

被引：38

作者：

Holmberg, Anna ^{[1
]}

Rasmussen, Magnus ^{[1
]}

机构：

[1] Lund Univ, Dept Clin Sci, Div Infect Med, Lund, Sweden

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2016年 / 84卷 / 01期

关键词：

Antibiotic susceptibility; Bacterial biofilm; Enterococcus faecalis; Enterococcus faecium; MBEC; IN-VITRO; VANCOMYCIN; INFECTION; COMBINATIONS; FOSFOMYCIN; RIFAMPICIN; EFFICACY; MODEL;

D O I：

10.1016/j.diagmicrobio.2015.09.012

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Enterococcus faecalis and Enterococcus faecium are important nosocomial pathogens that form biofilms on implanted materials. We compare the antibiotic sensitivity of bacteria in new (established during 24 hours) and mature (established during 120 hours) enterococcal biofilms. Mature biofilms contained more bacteria and were much more tolerant to antibiotics, including rifampicin-containing combinations, as judged by determination of minimal biofilm eradication concentrations and by time-kill experiments of bacteria in biofilms formed on beads of bone cement. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：19 / 21

页数：3

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