Reactive polymeric nanoparticles based on unconventional dextran derivatives

被引：23

作者：

Heinze, Th. ^{[1
]}

Michealis, N. ^{[1
]}

Hornig, St. ^{[1
]}

机构：

[1] Univ Jena, Ctr Excellence Polysaccharide Res, D-07743 Jena, Germany

来源：

EUROPEAN POLYMER JOURNAL | 2007年 / 43卷 / 03期

关键词：

polysaccharide; dextran; tosyl dextran; deoxy-azido dextran; synthesis; nanoparticles;

D O I：

10.1016/j.eurpolymj.2006.12.009

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Unconventional dextran derivatives with reactive tosyl- and deoxy-azido moieties were synthesized homogeneously under various reaction conditions. Well soluble tosyl dextran of a high degree of substitution up to 1.66 was prepared applying NN-dimethylacetamide/LiCl as solvent. Almost 50% of secondary toslyate moieties could be replaced by nucleophilic displacement reaction with azide ions. The structure of the products was efficiently analyzed by NMR spectroscopy also after peracylation of the unconventional dextran derivatives. Applying a simple dialysis technique, nanospheres with a size in the range from 160 to 420 nm (D50%) were obtained that possess reactive functional tosyl- and deoxy-azido groups. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：697 / 703

页数：7

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