Zwitterionic monomer graft copolymerization onto polyurethane surface through a PEG spacer

被引：112

作者：

Huang, Jingjing ^{[2
]}

Xu, Weilin ^{[1
,2
]}

机构：

[1] Wuhan Univ Sci & Engn, Minist Educ, Key Lab Green Proc & Funct Text New Text Mat, Wuhan 430073, Peoples R China

[2] Donghua Univ, Coll Text, Shanghai 201620, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2010年 / 256卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Graft copolymerization; Polyurethane; Surface modification; Zwitterions; Hemocompatibility; PLATELET ADHESIVE RESISTANCE; BLOOD COMPATIBILITY; POLY(ETHYLENE GLYCOL); CHEMICAL-MODIFICATION; SULFOBETAINE MONOMER; PROTEIN ADSORPTION; ACRYLIC-ACID; POLYMERIZATION; IMMOBILIZATION; HEPARIN;

D O I：

10.1016/j.apsusc.2010.01.051

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new zwitterionic surface was obtained by a novel three-step grafting procedure. The zwitterionic monomer was introduced by cerium-induced graft copolymerization in the presence of N,N'-methylene bisacrylamide (MBAA) as cross-linking agent. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) analysis confirmed the MBAA could stimulate zwitterionic monomer grafting onto themembrane surface. Surface properties were also determined by atomic force microscope (AFM) and water contact angle. The hemocompatibility of the modified PU membranes was evaluated by the activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT). The TT and APTT of PU were significantly prolonged by the zwitterion of sulfobetaine monomer grafting copolymerization. The new polyurethane membrane could have a great potential in biomedical applications. (C) 2010 Elsevier B V. All rights reserved.

引用

页码：3921 / 3927

页数：7

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