Aggregation-Induced Emission Luminogen Assisted Self-Assembly and Morphology Transition of Amphiphilic Glycopolypeptide with Bioimaging Application

被引：27

作者：

Chen, Huaijun ^{[1
,2
]}

Zhang, Ensong ^{[1
,2
]}

Yang, Guang ^{[1
,2
]}

Li, Long ^{[1
,2
]}

Wu, Libin ^{[1
,2
]}

Zhang, Yufei ^{[1
,2
]}

Liu, Yijiang ^{[1
,2
]}

Chen, Guosong ^{[1
,2
]}

Jiang, Ming ^{[1
,2
]}

机构：

[1] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[2] Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China

来源：

ACS MACRO LETTERS | 2019年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

COPOLYMERS;

D O I：

10.1021/acsmacrolett.9b00383

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Recently, fluorescent macromolecules with AIE effect have attracted considerable attentions due to their remarkable optical properties. In particular, designing novel tetraphenylethylene (TPE)-based bioconjugates to construct various self-assembled nanostructures and to expand the applications have aroused great interests. Herein, we report the self-assembly of TPE-based amphiphilic glycopolypeptide bioconjugate for bioimaging and tracing of live cells. The resultant amphiphilic fluorescent glycopolypeptide PltM-TPE could self-assemble into different nanostructures, including vesicles, spindles and porous nanosheets, which mainly depends on the water fraction in DMSO/water mixture. At the same time, the vesicles can transform to spindles when increasing the water fractions. Both the vesicles and spindles are prone to be effectively internalized by macrophages, and all of them performed outstanding intracellular fluorescent retention properties. As far as we know, this is the first report on self-assembly and applications of glycopolypeptide TPE bioconjugate, which will deepen our understanding on the self-assembly mechanism of TPE-based bioconjugates and provide a new way for fabricating functional fluorescent materials to monitor various biological processes.

引用

页码：893 / +

页数：11

共 26 条

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