Utilization of Mesenchymal Stem Cells in Kidney Transplantation: From Bench to Bedside

被引：1
作者：
Saidi, Reza F. [1 ]
Moghadasali, Reza [2 ,3 ]
Shekarchian, Soroosh [3 ]
机构：
[1] Univ Tehran Med Sci, Dept Surg, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran
[2] ACECR, Dept Stem Cells & Dev Biol, Cell Sci Res Ctr, Royan Inst Stem Cell Biol & Technol, Tehran, Iran
[3] ACECR, Dept Regenerat Biomed, Cell Sci Res Ctr, Royan Inst Stem Cell Biol & Technol, Tehran, Iran
来源：
IRANIAN JOURNAL OF KIDNEY DISEASES | 2019年 / 13卷 / 04期
关键词：
organ transplantation; stem cells; clinical trials; preclinical studies; mesenchymal stromal stem cell; SUPPRESS T-LYMPHOCYTE; STROMAL CELLS; RENAL-TRANSPLANTATION; DIFFERENTIATION CAPACITY; CYTOKINE PRODUCTION; CHANGING PATTERN; INTERFERON-GAMMA; ORGAN DONATION; INHIBIT; PROLIFERATION;
D O I：
暂无
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
There has been ample of preclinical and animal studies which showed efficacy and safety of using mesenchymal stem cells (MSCs) after transplantation for tissue repair, immunosuppression or tolerance induction. However, there has been a significant progress recently using MSCs in small clinical trials after transplantation. Recent results using MSCs after transplantation seem to be feasible and safe. However, there are some limitations to show the effectiveness of these cells including source, dose, timing and route of infusions. Currently, live donor kidney transplantation has been especially considered and development of recent regimes including immunosuppression drugs and MSCs administration to kidney and other organs and deceased donor transplantation would be crucial. Therefore, in this review we focused on immunomodulatory effects of MSCs that have been extensively studied to suppress various inflammatory responses in kidney transplantation.
引用
收藏
页码：213 / 224
页数：12
相关论文
共 86 条
[1]   Human mesenchymal stem cells modulate allogeneic immune cell responses [J].
Aggarwal, S ;
Pittenger, MF .
BLOOD, 2005, 105 (04) :1815-1822
[2]   The effect of injection using narrow-bore needles on mammalian cells: administration and formulation considerations for cell therapies [J].
Amer, Mahetab H. ;
White, Lisa J. ;
Shakesheff, Kevin M. .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2015, 67 (05) :640-650
[3]   Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway [J].
Augello, A ;
Tasso, R ;
Negrini, SM ;
Amateis, A ;
Indiveri, F ;
Cancedda, R ;
Pennesi, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (05) :1482-1490
[4]   Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models [J].
Bai, Lianhua ;
Lennon, Donald P. ;
Caplan, Arnold I. ;
DeChant, Anne ;
Hecker, Jordan ;
Kranso, Janet ;
Zaremba, Anita ;
Miller, Robert H. .
NATURE NEUROSCIENCE, 2012, 15 (06) :862-U86
[5]   Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness [J].
Beyth, S ;
Borovsky, Z ;
Mevorach, D ;
Liebergall, M ;
Gazit, Z ;
Aslan, H ;
Galun, E ;
Rachmilewitz, J .
BLOOD, 2005, 105 (05) :2214-2219
[6]   Mesenchymal stromal cells in renal transplantation: opportunities and challenges [J].
Casiraghi, Federica ;
Perico, Norberto ;
Cortinovis, Monica ;
Remuzzi, Giuseppe .
NATURE REVIEWS NEPHROLOGY, 2016, 12 (04) :241-253
[7]   Immunoregulation by Mesenchymal Stem Cells: Biological Aspects and Clinical Applications [J].
Castro-Manrreza, Marta E. ;
Montesinos, Juan J. .
JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 2015
[8]   A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells [J].
Chabannes, Dominique ;
Hill, Marcelo ;
Merieau, Emmanuel ;
Rossignol, Julien ;
Brion, Regis ;
Soulillou, Jean Paul ;
Anegon, Ignacio ;
Cuturi, Maria Cristina .
BLOOD, 2007, 110 (10) :3691-3694
[9]   Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing [J].
Chamberlain, Giselle ;
Fox, James ;
Ashton, Brian ;
Middleton, Jim .
STEM CELLS, 2007, 25 (11) :2739-2749
[10]   The interaction between mesenchymal stem cells and steroids during inflammation [J].
Chen, X. ;
Gan, Y. ;
Li, W. ;
Su, J. ;
Zhang, Y. ;
Huang, Y. ;
Roberts, A. I. ;
Han, Y. ;
Li, J. ;
Wang, Y. ;
Shi, Y. .
CELL DEATH & DISEASE, 2014, 5 :e1009-e1009
123456789