Heat shock proteins and kidney disease: perspectives of HSP therapy

被引：76

作者：

Chebotareva, Natalia ^{[1
]}

Bobkova, Irina ^{[1
]}

Shilov, Evgeniy ^{[1
]}

机构：

[1] IM Sechenov First Moscow State Med Univ, 2-4 Bolshaya Pirogovskaya St, Moscow 119992, Russia

来源：

CELL STRESS & CHAPERONES | 2017年 / 22卷 / 03期

关键词：

Kidney diseases; Molecular chaperones; Tissue protection; DNAvaccines; Tcell regulation; ISCHEMIA-REPERFUSION INJURY; NITRIC-OXIDE SYNTHASE; ACUTE-RENAL-FAILURE; NF-KAPPA-B; EPITOPE-SPECIFIC IMMUNOTHERAPY; JUVENILE IDIOPATHIC ARTHRITIS; HEME OXYGENASE-1 DEFICIENCY; HIGH UREA CONCENTRATIONS; PROXIMAL TUBULAR CELLS; REGULATORY T-CELLS;

D O I：

10.1007/s12192-017-0790-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heat shock proteins (HSPs) mediate a diverse range of cellular functions, prominently including folding and regulatory processes of cellular repair. A major property of these remarkable proteins, dependent on intracellular or extracellular location, is their capacity for immunoregulation that optimizes immune activity while avoiding hyperactivated inflammation. In this review, recent investigations are described, which examine roles of HSPs in protection of kidney tissue from various traumatic influences and demonstrate their potential for clinical management of nephritic disease. The HSP70 class is particularly attractive in this respect due to its multiple protective effects. The review also summarizes current understanding of HSP bioactivity in the pathophysiology of various kidney diseases, including acute kidney injury, diabetic nephropathy, chronic glomerulonephritis, and lupus nephritis-along with other promising strategies for their remediation, such as DNA vaccination.

引用

页码：319 / 343

页数：25

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