Interleukin 8 and cardiovascular disease

被引：237

作者：

Apostolakis, Stavros ^{[1
]}

Vogiatzi, Konstantina ^{[1
]}

Amanatidou, Virginia ^{[1
]}

Spandidos, Demetrios A. ^{[1
]}

机构：

[1] Univ Crete, Fac Med, Lab Clin Virol, Iraklion 71409, Crete, Greece

来源：

CARDIOVASCULAR RESEARCH | 2009年 / 84卷 / 03期

关键词：

Chemokines; Interleukin; 8; Cardiovascular disease; Biochemical markers; MONOCYTE CHEMOATTRACTANT PROTEIN-1; ACUTE MYOCARDIAL-INFARCTION; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; GENE-EXPRESSION; PLASMA-LEVELS; CYTOKINES INTERLEUKIN-6; TISSUE INHIBITOR; POTENTIAL ROLE; CHEMOKINES;

D O I：

10.1093/cvr/cvp241

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since the establishment of the inflammatory basis of atherosclerosis, several pro- or anti-inflammatory agents have been examined as potential mediators of the biochemical pathways of lesion formation. Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking and activation has advanced rapidly, especially in the field of cardiovascular disease. In the scientific literature, there is sufficient evidence to support beyond any doubt the involvement of IL-8 in the establishment and preservation of the inflammatory micro-environment of the insulted vascular wall. However, how the information derived from in vitro studies and animal models can be applied in clinical practice has yet to be determined. In the present review, the available evidence regarding the role of IL-8 in cardiovascular disease is presented, and future perspectives are discussed.

引用

页码：353 / 360

页数：8

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