Matrix Metalloproteinase-9 rs17576 Gene Polymorphism and Behcet's Disease: Is There an Association?

被引：10

作者：

Kamal, Asmaa ^{[1
]}

Elgengehy, Fatema T. ^{[2
]}

Abd Elaziz, Mohamed Momtaz ^{[3
]}

Gamal, Sherif M. ^{[2
]}

Sobhy, Nesreen ^{[2
]}

Medhat, Amira ^{[4
]}

El Dakrony, Al Hussein M. ^{[2
]}

机构：

[1] Cairo Univ, Dept Clin & Chem Pathol, Fac Med, 1 Al Saray St, Cairo 11562, Egypt

[2] Cairo Univ, Dept Rheumatol & Rehabil, Fac Med, Cairo, Egypt

[3] Cairo Univ, Internal Med Dept, Fac Med, Cairo, Egypt

[4] Natl Res Ctr, Complementary Med Dept, Cairo, Egypt

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2017年 / 46卷 / 05期

关键词：

Behcet's disease; gene polymorphism; matrix metalloproteinase; MMP-9; rs17576; GELATINASE-B; MMP-9;

D O I：

10.1080/08820139.2017.1296857

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Clinical studies have reported a significant association between matrix metalloproteinases (MMP), particularly (MMP-9), and inflammatory diseases including Behcet's disease (BD).Purpose: To study the relationship between MMP-9 rs17576 gene polymorphism and the development of BD, and its relation to disease activity among Egyptian patients.Methods: A total of 100 BD patients and 100 healthy control volunteers were genotyped for MMP-9 rs17576 polymorphism with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), followed by the confirmation of our results in random subgroups using direct DNA sequencing technique.Results: The frequency of the GG genotype and G allele was significantly higher in BD patients as compared to the normal controls (p = 0.011, OR 8.61; p = 0.03, OR 1.65, respectively). There was no significant association between the MMP-9 rs17576 polymorphism and the clinical outcomes of BD.Conclusion: our study suggests a significant association of the MMP-9 rs17576 A/G polymorphism with increased risk of BD development in Egyptian patients.

引用

页码：460 / 468

页数：9

共 35 条

[1] The determination of matrix metalloproteinase 9 activity and gene expression levels in Behcet's disease patients with aneurysmal complications [J].

Aksoy, Yasemin ;

Ercan, Ayse ;

Dalmizrak, Ozlem ;

Canpinar, Hande ;

Durmazlar, Selda Pelin Kartal ;

Bayazit, Murat .

CLINICAL RHEUMATOLOGY, 2011, 30 (04) :515-519

[2] BINDING OF GELATINASES A AND B TO TYPE-I COLLAGEN AND OTHER MATRIX COMPONENTS [J].

ALLAN, JA ;

DOCHERTY, AJP ;

BARKER, PJ ;

HUSKISSON, NS ;

REYNOLDS, JJ ;

MURPHY, G .

BIOCHEMICAL JOURNAL, 1995, 309 :299-306

[3] Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness [J].

Armstrong, Christine ;

Abilleira, Sonia ;

Sitzer, Matthias ;

Markus, Hugh S. ;

Bevan, Steve .

STROKE, 2007, 38 (11) :2895-2899

[4] Chemokines in the CNS: plurifunctional mediators in diverse states [J].

Asensio, VC ;

Campbell, IL .

TRENDS IN NEUROSCIENCES, 1999, 22 (11) :504-512

[5] Matrix metalloproteinase-9 genetic variations affect MMP-9 levels in obese children [J].

Belo, V. A. ;

Souza-Costa, D. C. ;

Luizon, M. R. ;

Lanna, C. M. M. ;

Carneiro, P. C. ;

Izidoro-Toledo, T. C. ;

Ferraz, K. C. ;

Tanus-Santos, J. E. .

INTERNATIONAL JOURNAL OF OBESITY, 2012, 36 (01) :69-75

[6] Effectiveness and tuberculosis-related safety profile of interleukin-1 blocking agents in the management of Behcet's disease [J].

Cantarini, Luca ;

Lopalco, Giuseppe ;

Caso, Francesco ;

Costa, Luisa ;

Iannone, Florenzo ;

Lapadula, Giovanni ;

Anelli, Maria Grazia ;

Franceschini, Rossella ;

Menicacci, Cristina ;

Galeazzi, Mauro ;

Selmi, Carlo ;

Rigante, Donato .

AUTOIMMUNITY REVIEWS, 2015, 14 (01) :1-9

[7]

Chiang TY, 2012, CLIN CHEM LAB MED, V50, P449, DOI [10.1515/CCLM.2011.805, 10.1515/cclm.2011.805]

[8] Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines [J].

Choke, Edward ;

Thompson, Matthew M. ;

Dawson, Joseph ;

Wilson, W. Richard W. ;

Sayed, Saiqa ;

Loftus, Ian M. ;

Cockerill, Gillian W. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (09) :2077-2082

[9] Involvement of gelatinases (MMP-2 and MMP-9) in the development of airway inflammation and pulmonary fibrosis [J].

Corbel, M ;

Belleguic, C ;

Boichot, E ;

Lagente, V .

CELL BIOLOGY AND TOXICOLOGY, 2002, 18 (01) :51-61

[10] The International Criteria for Behcet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria [J].

Davatchi, F. ;

Assaad-Khalil, S. ;

Calamia, K. T. ;

Crook, J. E. ;

Sadeghi-Abdollahi, B. ;

Schirmer, M. ;

Tzellos, T. ;

Zouboulis, C. C. ;

Akhlagi, M. ;

Al-Dalaan, A. ;

Alekberova, Z. S. ;

Ali, A. A. ;

Altenburg, A. ;

Arromdee, E. ;

Baltaci, M. ;

Bastos, M. ;

Benamour, S. ;

Ben Ghorbel, I. ;

Boyvat, A. ;

Carvalho, L. ;

Chen, W. ;

Ben-Chetrit, E. ;

Chams-Davatchi, C. ;

Correia, J. A. ;

Crespo, J. ;

Dias, C. ;

Dong, Y. ;

Paixao-Duarte, F. ;

Elmuntaser, K. ;

Elonakov, A. V. ;

Grana Gil, J. ;

Haghdoost, A-A. ;

Hayani, R. M. ;

Houman, H. ;

Isayeva, A. R. ;

Jamshidi, A. R. ;

Kaklamanis, P. ;

Kumar, A. ;

Kyrgidis, A. ;

Madanat, W. ;

Nadji, A. ;

Namba, K. ;

Ohno, S. ;

Olivieri, I. ;

Vaz Patto, J. ;

Pipitone, N. ;

de Queiroz, M. V. ;

Ramos, F. ;

Resende, C. ;

Rosa, C. M. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2014, 28 (03) :338-347

← 1 2 3 4 →