TEDDY- : The environmental determinants of diabetes in the young -: An observational clinical trial

被引：79
作者：
Hagopian, William A.
Lernmark, Ake
Rewers, Marian J.
Simell, Olli G.
She, Jin-Xiong
Ziegler, Anette G.
Krischer, Jeffrey P.
Akolkar, Beena
机构：
[1] Univ Hosp MAS, Malmo 20522, Sweden
[2] Pacific NW Res Inst, Seattle, WA 98122 USA
[3] Univ Colorado, Denver, CO 80162 USA
[4] Med Coll Georgia, Augusta, GA 30912 USA
[5] Univ Turku, Cent Hosp, FIN-20520 Turku, Finland
[6] Diabet Res Inst, D-80804 Munich, Germany
[7] Univ S Florida, Tampa, FL 33612 USA
[8] NIH, Bethesda, MD 20892 USA
来源：
IMMUNOLOGY OF DIABETES IV: PROGRESS IN OUR UNDERSTANDING | 2006年 / 1079卷
关键词：
type; 1; diabetes; islet autoantibodies; HLA; virus;
D O I：
10.1196/annals.1375.049
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.
引用
收藏
页码：320 / 326
页数：7
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