Molecular identity, synaptic localization, and physiology of calcium channels in retinal bipolar cells

被引：66

作者：

Berntson, A ^{[1
]}

Taylor, WR ^{[1
]}

Morgans, CW ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Ctr Visual Sci, Canberra, ACT 2601, Australia

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2003年 / 71卷 / 01期

关键词：

mouse; electrophysiology; patch-clamp; alpha; 1F; immunohistochemistry;

D O I：

10.1002/jnr.10459

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bipolar cells convey information through the retina via graded changes in their membrane potential and modulate transmitter release through the influx of calcium via L-type calcium channels. However, the molecular identity of the a, subunit has not been confirmed. We report the presence of the newly cloned alpha(1F) subunit in mouse bipolar cell synaptic terminals. The alpha(1F) subunits are localized to hot spots, possibly corresponding to active zones. We also report the physiological properties of two calcium currents present in mouse bipolar cells, a low-voltage-activated L-type current and a low-voltage-activated T-type calcium cur-rent. The physiological properties of the T-type current suggest that it is completely inactivated under physiological conditions. The L-type current may be mediated by the alpha(1F) subunit, and influx of calcium through the alpha(1F) channel may control neurotransmitter release from the bipolar cell terminal. (C) 2002 willey-Liss, Inc.

引用

页码：146 / 151

页数：6

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