Proinflammatory and antimicrobial nitric oxide in gingival fluid of diabetic patients with periodontal disease

被引：23
作者：
Skaleric, Uros
Gaspirc, Boris
McCartney-Francis, Nancy
Masera, Andrej
Wahl, Sharon M.
机构：
[1] Univ Ljubljana, Fac Med, Dept Oral Med & Periodontol, Ljubljana 1000, Slovenia
[2] NIDCR, Oral Infect & Immun Branch, NIH, Bethesda, MD USA
[3] Univ Ljubljana, Fac Med, Inst Pathol, Ljubljana 61000, Slovenia
来源：
INFECTION AND IMMUNITY | 2006年 / 74卷 / 12期
关键词：
D O I：
10.1128/IAI.00071-06
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.
引用
收藏
页码：7010 / 7013
页数：4
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