Study of retention parameters obtained in RP-TLC system and their application on QSAR/QSPR of some alpha adrenergic and imidazoline receptor ligands

被引：18

作者：

Eric, S. ^{[1
]}

Pavlovic, A. ^{[1
]}

Popovic, G. ^{[1
]}

Agbaba, D. ^{[1
]}

机构：

[1] Univ Belgrade, Fac Pharm, Belgrade 11000, Serbia

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 2007年 / 45卷 / 03期

关键词：

D O I：

10.1093/chromsci/45.3.140

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The retention constant (110) is determined for 11 selected adrenergic and imidazoline receptor ligands by reverse-phase-thin layer chromatography. It is established that the retention behavior of investigated compounds mostly depends on geometrical, electrostatic, and hydrogen bonding properties. Good correlations among hydrophobic parameters R-m(0) versus log P for all eleven tested compounds are obtained. The satisfactory correlations are found between R-m(0) versus apparent partition coefficient octanol-buffer pH 7.4 (log P-1) or apparent partition coefficient in four liposome systems (log K-M(1)) and hypotensive activity (pC(25)) for five imidazolines. The results confirm the suitability of this parameter in quantitative structure-property and structure-activity relationships studies of these drugs.

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页码：140 / 145

页数：6

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