Passive mechanical properties of cardiac tissues in heart hypertrophy during pregnancy

被引：12

作者：

Virgen-Ortiz, Adolfo ^{[1
]}

Marin, J. L. ^{[2
]}

Elizalde, A. ^{[3
]}

Castro, E. ^{[4
]}

Stefani, E. ^{[5
,6
]}

Toro, L. ^{[5
,7
]}

Muniz, J. ^{[3
]}

机构：

[1] Univ Sonora, Unidad Reg Campus Navojoa, Dept Ciencias Quim Biol, Navojoa 85880, Sonora, Mexico

[2] Univ Sonora, Dept Invest Fis, Hermosillo 83000, Sonora, Mexico

[3] Univ Colima, Ctr Univ Invest Biomed, Unidad Invest Enrico Stefani Bonfanti, Colima, Mexico

[4] Univ Colima, Ctr Univ Invest Biomed, Unidad Invest Carlos Mendez, Colima, Mexico

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF PHYSIOLOGICAL SCIENCES | 2009年 / 59卷 / 05期

关键词：

Cardiac hypertrophy; Pregnancy; Passive tension; DILATED CARDIOMYOPATHY; VOLUME OVERLOAD; TITIN ISOFORMS; VOLUNTARY EXERCISE; SKELETAL-MUSCLE; STIFFNESS; RAT; EXPRESSION; MYOCYTES; COLLAGEN;

D O I：

10.1007/s12576-009-0047-5

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We evaluated changes in passive mechanical properties in cardiac tissues during rat pregnancy. Left and right ventricular free walls were dissected from hearts of nonpregnant, late-pregnant, and postpartum rats. Mechanical experiments in ventricular strips were done by stretch-release cycles using a step motor. The results show that during pregnancy, there is cardiac hypertrophy associated with (1) an increase in myocyte size, particularly of augmented myocyte length, (2) a decrease in passive tension developed by the myocardial walls, and (3) a decrease in both elastic modulus and hysteresis. All changes observed during rat pregnancy were reversed during postpartum. In conclusion, a heart with less ventricular rigidity could contribute to facilitating the ventricular filling in conditions of a greater circulating volume characteristic of pregnancy.

引用

页码：391 / 396

页数：6

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