Nutriepigenomics and malnutrition

被引：14

作者：

de Luca, Arnaud ^{[1
,2
]}

Hankard, Regis ^{[2
,3
]}

Borys, Jean-Michel ^{[4
]}

Sinnett, Daniel ^{[1
,5
]}

Marcil, Valerie ^{[1
,6
]}

Levy, Emile ^{[1
,4
,6
]}

机构：

[1] Sainte Justine Univ Hosp Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] INSERM, U1069, F-37044 Tours, France

[3] Francois Rabelais Univ, F-37000 Tours, France

[4] EPODE Int Network, F-75017 Paris, France

[5] Univ Montreal, Fac Med, Dept Pediat, Montreal, PQ H3T IJ4, Canada

[6] Univ Montreal, Fac Med, Dept Nutr, Montreal, PQ H3T IJ4, Canada

来源：

EPIGENOMICS | 2017年 / 9卷 / 06期

基金：

加拿大健康研究院;

关键词：

carbohydrate metabolism; cholesterol metabolism; epigenetic therapy; lipid metabolism; malnutrition; metabolic diseases; nutrigenomics; nutritional intervention; polyphenols; ALTERED EPIGENETIC REGULATION; DIETARY-PROTEIN RESTRICTION; FOLIC-ACID SUPPLEMENTATION; ONE-CARBON METABOLISM; LONG-TERM HEALTH; DNA METHYLATION; PRENATAL EXPOSURE; CHINESE FAMINE; MATERNAL DIET; EARLY-LIFE;

D O I：

10.2217/epi-2016-0168

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenetics is defined as the modulation of gene expression without changes to the underlying DNA sequence. Epigenetic alterations, as a consequence of in utero malnutrition, may play a role in susceptibility to develop adulthood diseases and inheritance. However, the mechanistic link between epigenetic modifications and abnormalities in nutrition remains elusive. This review provides an update on the association of suboptimal nutritional environment and the high propensity to produce adult-onset chronic illnesses with a particular focus on modifications in genome functions that occur without alterations to the DNA sequence. We will mention the drivers of the phenotype and pattern of epigenetic markers set down during the reprogramming along with novel preventative and therapeutic strategies. New knowledge of epigenetic alterations is opening a gate toward personalized medicine.

引用

页码：893 / 917

页数：25

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