Nutriepigenomics and malnutrition

被引：14

作者：

de Luca, Arnaud ^{[1
,2
]}

Hankard, Regis ^{[2
,3
]}

Borys, Jean-Michel ^{[4
]}

Sinnett, Daniel ^{[1
,5
]}

Marcil, Valerie ^{[1
,6
]}

Levy, Emile ^{[1
,4
,6
]}

机构：

[1] Sainte Justine Univ Hosp Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada

[2] INSERM, U1069, F-37044 Tours, France

[3] Francois Rabelais Univ, F-37000 Tours, France

[4] EPODE Int Network, F-75017 Paris, France

[5] Univ Montreal, Fac Med, Dept Pediat, Montreal, PQ H3T IJ4, Canada

[6] Univ Montreal, Fac Med, Dept Nutr, Montreal, PQ H3T IJ4, Canada

来源：

EPIGENOMICS | 2017年 / 9卷 / 06期

基金：

加拿大健康研究院;

关键词：

carbohydrate metabolism; cholesterol metabolism; epigenetic therapy; lipid metabolism; malnutrition; metabolic diseases; nutrigenomics; nutritional intervention; polyphenols; ALTERED EPIGENETIC REGULATION; DIETARY-PROTEIN RESTRICTION; FOLIC-ACID SUPPLEMENTATION; ONE-CARBON METABOLISM; LONG-TERM HEALTH; DNA METHYLATION; PRENATAL EXPOSURE; CHINESE FAMINE; MATERNAL DIET; EARLY-LIFE;

D O I：

10.2217/epi-2016-0168

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenetics is defined as the modulation of gene expression without changes to the underlying DNA sequence. Epigenetic alterations, as a consequence of in utero malnutrition, may play a role in susceptibility to develop adulthood diseases and inheritance. However, the mechanistic link between epigenetic modifications and abnormalities in nutrition remains elusive. This review provides an update on the association of suboptimal nutritional environment and the high propensity to produce adult-onset chronic illnesses with a particular focus on modifications in genome functions that occur without alterations to the DNA sequence. We will mention the drivers of the phenotype and pattern of epigenetic markers set down during the reprogramming along with novel preventative and therapeutic strategies. New knowledge of epigenetic alterations is opening a gate toward personalized medicine.

引用

页码：893 / 917

页数：25

共 151 条

[51] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice [J].

Horie, Takahiro ;

Nishino, Tomohiro ;

Baba, Osamu ;

Kuwabara, Yasuhide ;

Nakao, Tetsushi ;

Nishiga, Masataka ;

Usami, Shunsuke ;

Izuhara, Masayasu ;

Sowa, Naoya ;

Yahagi, Naoya ;

Shimano, Hitoshi ;

Matsumura, Shigenobu ;

Inoue, Kazuo ;

Marusawa, Hiroyuki ;

Nakamura, Tomoyuki ;

Hasegawa, Koji ;

Kume, Noriaki ;

Yokode, Masayuki ;

Kita, Toru ;

Kimura, Takeshi ;

Ono, Koh .

NATURE COMMUNICATIONS, 2013, 4

[52] Early Life Exposure to the 1959-1961 Chinese Famine Has Long-Term Health Consequences [J].

Huang, Cheng ;

Li, Zhu ;

Wang, Meng ;

Martore, Reynaldo .

JOURNAL OF NUTRITION, 2010, 140 (10) :1874-1878

[53] Hypertension, Diabetes and Overweight: Looming Legacies of the Biafran Famine [J].

Hult, Martin ;

Tornhammar, Per ;

Ueda, Peter ;

Chima, Charles ;

Bonamy, Anna-Karin Edstedt ;

Ozumba, Benjamin ;

Norman, Mikael .

PLOS ONE, 2010, 5 (10)

[54] MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism [J].

Iliopoulos, Dimitrios ;

Drosatos, Konstantinos ;

Hiyama, Yaeko ;

Goldberg, Ira J. ;

Zannis, Vassilis I. .

JOURNAL OF LIPID RESEARCH, 2010, 51 (06) :1513-1523

[55] Aging and epigenetic drift: a vicious cycle [J].

Issa, Jean-Pierre .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (01) :24-29

[56] The role of nutrition on epigenetic modifications and their implications on health [J].

Jimenez-Chillaron, Josep C. ;

Diaz, Ruben ;

Martinez, Debora ;

Pentinat, Thais ;

Ramon-Krauel, Marta ;

Ribo, Silvia ;

Plosch, Torsten .

BIOCHIMIE, 2012, 94 (11) :2242-2263

[57] Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome [J].

Jousse, Celine ;

Parry, Laurent ;

Lambert-Langlais, Sarah ;

Maurin, Anne-Catherine ;

Averous, Julien ;

Bruhat, Alain ;

Carraro, Valerie ;

Tost, Jorg ;

Letteron, Philippe ;

Chen, Patty ;

Jockers, Ralf ;

Launay, Jean-Marie ;

Mallet, Jacques ;

Fafournoux, Pierre .

FASEB JOURNAL, 2011, 25 (09) :3271-3278

[58] Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice [J].

Joven, Jorge ;

Espinel, Eugenia ;

Rull, Anna ;

Aragones, Gerard ;

Rodriguez-Gallego, Esther ;

Camps, Jordi ;

Micol, Vicente ;

Herranz-Lopez, Maria ;

Menendez, Javier A. ;

Borras, Isabel ;

Segura-Carretero, Antonio ;

Alonso-Villaverde, Carlos ;

Beltran-Debon, Raul .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (07) :894-899

[59] Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period [J].

Kaati, G ;

Bygren, LO ;

Edvinsson, S .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2002, 10 (11) :682-688

[60] Royalactin induces queen differentiation in honeybees [J].

Kamakura, Masaki .

NATURE, 2011, 473 (7348) :478-483

← 1 2 3 4 5 6 7 8 9 10 →