Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report

被引：4

作者：

Adan, Alfredo ^{[1
]}

Moll-Udina, Aina ^{[1
]}

Ramirez, Julio ^{[2
]}

Llorenc, Victor ^{[1
]}

机构：

[1] Hosp Clin Barcelona, Dept Ophthalmol, Calle Sabino de Arana 1, E-08036 Barcelona, Spain

[2] Hosp Clin Barcelona, Dept Rheumatol, Barcelona, Spain

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2021年 / 29卷 / 01期

关键词：

uveitis; juvenile idiopathic arthritis; cystoid macular edema; tocilizumab; subcutaneous;

D O I：

10.1080/09273948.2019.1644350

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To report a case of cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. Case report: 26-year-old female patient presented with CME in both eyes. CME became refractory and TCZ-IV was initiated. After 12 infusions was stopped because grade 1 neuropenia developed. On examination,visual acuity of the right eye was 20/80. Spectral domain optical coherence tomography (SD-OCT) of the right eye revealed CME. Subcutaneous (TCZ-SC) was initiated. After six injections of TCZ-SC, ophthalmic examination revealed no signs of active inflammation, and central foveal thickness decreased. Conclusion: TCZ-SC seems to have a role in the treatment of CME secondary to juvenile idiopathic arthritis (JIA)-associated uveitis

引用

页码：6 / 8

页数：3

共 6 条

[1] Tocilizumab treatment for refractory uveitis-related cystoid macular edema [J].

Adan, Alfredo ;

Mesquida, Marina ;

Llorenc, Victor ;

Espinosa, Gerard ;

Molins, Blanca ;

Hernandez, Maria V. ;

Pelegrin, Laura .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2013, 251 (11) :2627-2632

[2] Tocilizumab Effectiveness After Switching from Intravenous to Subcutaneous Route in Patients with Rheumatoid Arthritis: The RoSwitch Study [J].

Darloy, Jean ;

Segaud, Nicolas ;

Salmon, Jean-Hugues ;

Eschard, Jean-Paul ;

Goeb, Vincent ;

Deprez, Xavier ;

Guyot, Marie-Helene ;

Houvenagel, Eric ;

Lecuyer, Nicolas ;

Marguerie, Laurent ;

Gally, Samuel ;

Pau, David ;

Idier, Isabelle ;

Baudens, Guy ;

Flipo, Rene-Marc .

RHEUMATOLOGY AND THERAPY, 2019, 6 (01) :61-75

[3] Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis [J].

De Benedetti, Fabrizio ;

Brunner, Hermine I. ;

Ruperto, Nicolino ;

Kenwright, Andrew ;

Wright, Stephen ;

Calvo, Inmaculada ;

Cuttica, Ruben ;

Ravelli, Angelo ;

Schneider, Rayfel ;

Woo, Patricia ;

Wouters, Carine ;

Xavier, Ricardo ;

Zemel, Lawrence ;

Baildam, Eileen ;

Burgos-Vargas, Ruben ;

Dolezalova, Pavla ;

Garay, Stella M. ;

Merino, Rosa ;

Joos, Rik ;

Grom, Alexei ;

Wulffraat, Nico ;

Zuber, Zbigniew ;

Zulian, Francesco ;

Lovell, Daniel ;

Martini, Alberto .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (25) :2385-2395

[4] TWENTY-FOUR MONTH FOLLOW-UP OF TOCILIZUMAB THERAPY FOR REFRACTORY UVEITIS- RELATED MACULAR EDEMA [J].

Mesquida, Marina ;

Molins, Blanca ;

Llorenc, Victor ;

Hernandez, Maria V. ;

Espinosa, Gerard ;

Sainz De la Maza, Maite ;

Adan, Alfredo .

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2018, 38 (07) :1361-1370

[5] Subcutaneous Tocilizumab May Be Less Effective than Intravenous Tocilizumab in the Treatment of Juvenile Idiopathic Arthritis-associated Uveitis [J].

Quesada-Masachs, Estefania ;

Modesto Caballero, Consuelo .

JOURNAL OF RHEUMATOLOGY, 2017, 44 (02) :260-261

[6] Evidence for Tocilizumab as a Treatment Option in Refractory Uveitis Associated with Juvenile Idiopathic Arthritis [J].

Tappeiner, Christoph ;

Mesquida, Marina ;

Adan, Alfredo ;

Anton, Jordi ;

Ramanan, Athimalaipet V. ;

Carreno, Ester ;

Mackensen, Friederike ;

Kotaniemi, Kaisu ;

de Boer, Joke H. ;

Bou, Rosa ;

Garcia de Vicuna, Carmen ;

Heiligenhaus, Arnd .

JOURNAL OF RHEUMATOLOGY, 2016, 43 (12) :2183-2188

← 1 →