T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils

被引：12
|
作者：
Samadi, Nazanin [1 ]
Polak, Dominika [1 ]
Kitzmueller, Claudia [1 ]
Steinberger, Peter [2 ]
Zlabinger, Gerhard J. [2 ]
Jahn-Schmid, Beatrice [1 ]
Bohle, Barbara [1 ]
机构：
[1] Med Univ Vienna, Dept Pathophysiol & Allergy Res, Waehringer Guertel 18-20, A-1090 Vienna, Austria
[2] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Inst Immunol, Vienna, Austria
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2019年 / 49卷 / 09期
基金：
奥地利科学基金会;
关键词：
Allergen-specific T cells; Allergy; Neutrophils; Th1; Th2; CD4(+);
D O I：
10.1002/eji.201848057
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.
引用
收藏
页码：1441 / 1443
页数：3
相关论文
共 50 条
  • [1] Human neutrophils require short exposure to cytokines and allergen to become functional antigen-presenting cells
    Polak, Dominika
    Elbe-Buerger, Adelheid
    Kitzmueller, Claudia
    Zlabinger, Gerhard J.
    Bohle, Barbara
    ALLERGY, 2023, 78 (01) : 291 - 293
  • [2] Unleashing the power of antigen-presenting neutrophils
    Wu, Yingcheng
    Ma, Jiaqiang
    Gao, Qiang
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2024, 16 (06)
  • [3] Neutrophils Are Atypical Antigen-Presenting Cells
    Vorobjeva N.V.
    Moscow University Biological Sciences Bulletin, 2023, 78 (2) : 45 - 52
  • [4] THE ANTIGEN-PRESENTING CAPACITY OF HUMAN EPIDERMAL LANGERHANS CELLS
    PEGUETNAVARRO, J
    MOULON, C
    SCHMITT, D
    CELLULAR AND MOLECULAR BIOLOGY, 1994, 40 : 15 - 20
  • [5] 'Anergic' T cells modulate the T-cell activating capacity of antigen-presenting cells
    Taams, LS
    Boot, EPJ
    van Eden, W
    Wauben, MHM
    JOURNAL OF AUTOIMMUNITY, 2000, 14 (04) : 335 - 341
  • [6] Effect of calcitriol on the production of T-cell-derived cytokines in psoriasis
    Barna, M
    Bos, JD
    Kapsenberg, ML
    Snijdewint, FGM
    BRITISH JOURNAL OF DERMATOLOGY, 1997, 136 (04) : 536 - 541
  • [7] From the antigen-presenting cell to the antigen-presenting vesicle:: The exosomes
    Schartz, NEC
    Chaput, N
    André, F
    Zitvogel, L
    CURRENT OPINION IN MOLECULAR THERAPEUTICS, 2002, 4 (04) : 372 - 381
  • [8] T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules
    Rossjohn, Jamie
    Gras, Stephanie
    Miles, John J.
    Turner, Stephen J.
    Godfrey, Dale I.
    McCluskey, James
    ANNUAL REVIEW OF IMMUNOLOGY VOL 33, 2015, 33 : 169 - 200
  • [9] Targeting of Human Antigen-Presenting Cell Subsets
    Goyvaerts, Cleo
    Dingemans, Jozef
    De Groeve, Kurt
    Heirman, Carlo
    Van Gulck, Ellen
    Vanham, Guido
    De Baetselier, Patrick
    Thielemans, Kris
    Raes, Geert
    Breckpot, Karine
    JOURNAL OF VIROLOGY, 2013, 87 (20) : 11304 - 11308
  • [10] Antigen-Presenting Cell-Like Neutrophils Foster T Cell Response in Hyperlipidemic Patients and Atherosclerotic Mice
    Zhao, Tingrui
    Jiang, Qingsong
    Li, Wenming
    Wang, Yin
    Zou, Yao
    Chai, Xinyu
    Yuan, Zhiyi
    Ma, Limei
    Yu, Ruihong
    Deng, Tao
    Yu, Chao
    Wang, Tingting
    FRONTIERS IN IMMUNOLOGY, 2022, 13
12345