Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice

被引：23
作者：
Arque, Gloria
Martinez de Lagran, Maria
Arbones, Maria L.
Dierssen, Mara [1 ]
机构：
[1] Pompeu Fabra Univ, CRG, Genes & Dis Program, Barcelona, Spain
来源：
NEUROBIOLOGY OF DISEASE | 2009年 / 36卷 / 02期
关键词：
DYRK1A; Aging; Visuo-spatial learning and memory; Motor dysfunction; Radial-arm water maze; TYROSINE-REGULATED KINASE-1A; AMYLOID PRECURSOR PROTEIN; SYNDROME CRITICAL REGION; DOWN-SYNDROME; TRANSGENIC MICE; ALZHEIMER-DISEASE; NEUROFIBRILLARY DEGENERATION; FUNCTIONAL-LINK; HUMAN HOMOLOG; TAU-PROTEIN;
D O I：
10.1016/j.nbd.2009.07.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/-) exhibit decreased brain size, motor abnormalities and cognitive deficits in the adult. However, there is no information about the mutant phenotype in old ages. Here we analyze the impact of Dyrk1A dosage reduction on motor performance and hippocampal-dependent learning and memory in aged Dyrk1A+/- mice. Whereas motor tests showed marked alterations in traction ability, prehensile reflex and balance, heterozygous mice only present a slight impairment of visuo-spatial memory even though they show a robust decrease of CA1-CA3 and dentate gyrus cells. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：312 / 319
页数：8
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