Relationship of serum bilirubin concentrations to kidney function and albuminuria in the United States adult population. Findings from the National Health and Nutrition Examination Survey 2001-2006

被引:44
作者
Targher, Giovanni [1 ]
Bosworth, Cortney [2 ]
Kendrick, Jessica [2 ]
Smits, Gerard [2 ]
Lippi, Giuseppe [3 ]
Chonchol, Michel [2 ]
机构
[1] Univ Verona, Endocrinol Sect, Dept Biomed & Surg Sci, I-37126 Verona, Italy
[2] Univ Colorado, Denver Hlth Sci Ctr, Div Renal Dis & Hypertens, Denver, CO 80202 USA
[3] Univ Hosp Verona, Sect Clin Chem, Dept Biomed & Morphol Sci, Verona, Italy
关键词
albuminuria; bilirubin; epidemiology; estimated glomerular filtration rate; liver dysfunction; FATTY LIVER-DISEASE; CORONARY-ARTERY-DISEASE; ISCHEMIC-HEART-DISEASE; CARDIOVASCULAR-DISEASE; INCREASED RISK; NONALCOHOLIC STEATOHEPATITIS; RENAL-INSUFFICIENCY; OXIDATIVE STRESS; MEDICAL PROGRESS; NITRIC-OXIDE;
D O I
10.1515/CCLM.2009.244
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: The association of serum bilirubin concentrations with kidney function and albuminuria has not been established in the US general population. Methods: We performed a cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) 2001-2006 and examined the associations of serum total bilirubin concentrations with estimated glomerular filtration rate (eGFR) and albuminuria in a nationally representative sample of 13,184 adults aged 20 years or older. eGFR was estimated using the abbreviated Modification of Diet in Renal Disease equation. Urinary albumin excretion was measured using the albumin/creatinine ratio. Results: An eGFR < 60 mL/min/1.73 m(2) and urinary albumin/creatinine ratio >= 30 mg/g were present in 8.1% (n=1072) and 10.6% (n=1402) of participants, respectively. A total of 427 (3.2%) individuals had a serum total bilirubin concentration > 22.23 mu mol/L. After adjustment for demographics, comorbidities, alcohol consumption, viral hepatitis status and other laboratory measures, serum bilirubin was negatively associated with eGFR, and positively with albuminuria both in the whole cohort and in the subgroup of non-diabetic individuals. In contrast, serum bilirubin was not significantly associated with eGFR or albuminuria in persons with diabetes (n=1253). Conclusions: Increasing serum concentrations of total bilirubin are independently associated with decreasing eGFR and increasing albuminuria in the US adult population. Clin Chem Lab Med 2009;47:1055-62.
引用
收藏
页码:1055 / 1062
页数:8
相关论文
共 50 条
[41]   Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES) [J].
Schleicher, Rosemary L. ;
Carroll, Margaret D. ;
Ford, Earl S. ;
Lacher, David A. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 90 (05) :1252-1263
[42]   Association between exposure to fine particulate matter and kidney function: Results from the Korea National Health and Nutrition Examination Survey [J].
Oh, Jongmin ;
Ye, Shinhee ;
Kang, Duk-Hee ;
Ha, Eunhee .
ENVIRONMENTAL RESEARCH, 2022, 212
[43]   Association between periodontitis and osteoporosis in United States adults from the National Health and Nutrition Examination Survey: a cross-sectional analysis [J].
Peng, Jing ;
Chen, Jianming ;
Liu, Yucheng ;
Lyu, Jun ;
Zhang, Bin .
BMC ORAL HEALTH, 2023, 23 (01)
[44]   Berry Consumption and Sleep in the Adult US General Population: Results from the National Health and Nutrition Examination Survey 2005-2018 [J].
Zhang, Li ;
Muscat, Joshua E. ;
Kris-Etherton, Penny M. ;
Chinchilli, Vernon M. ;
Fernandez-Mendoza, Julio ;
Al-Shaar, Laila ;
Richie, John P. .
NUTRIENTS, 2023, 15 (24)
[45]   Association between self-reported sleep apnea and albuminuria among middle age and elderly population: Results from National Health and Nutrition Examination Survey [J].
Chen, Li-Da ;
Lin, Xiao-Fen ;
Xu, Qiao-Zhen ;
Cai, Zhi-Ming ;
Zhou, Ji-Guang ;
Lin, Li ;
Zhang, Xiao-Bin .
MEDICINE, 2025, 104 (06) :e41515
[46]   The relationship between fecal incontinence and food insecurity in United States women: an analysis of 2005e2010 National Health and Nutrition Examination Survey [J].
Okada, Chihiro ;
Kim, Joseph I. ;
Melamed, Michal L. ;
Abraham, Nitya ;
Halani, Priyanka Kadam .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2023, 228 (04) :449.e1-449.e13
[47]   Relationship between Urinary Phthalate and Bisphenol A Concentrations and Serum Thyroid Measures in US Adults and Adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008 [J].
Meeker, John D. ;
Ferguson, Kelly K. .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2011, 119 (10) :1396-1402
[48]   Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey [J].
Jeong, Hyemin ;
Baek, Sun-Young ;
Kim, Seon-Woo ;
Park, Eun-Jung ;
Kim, Hyungjin ;
Lee, Jaejoon ;
Jeon, Chan-Hong .
MEDICINA-LITHUANIA, 2021, 57 (09)
[49]   Exploring the role of uterine fibroids in promotion of cardiovascular diseases by diabetes exposure: Findings from national health and nutrition examination survey 1999-2006 [J].
Li, Bin ;
Yuan, Zhen ;
Zhang, Yizhi ;
Li, Feng ;
Huang, Lin ;
Yang, Zhihui ;
Liu, Haiyue ;
Liu, Zuheng .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
[50]   Association of dietary and serum selenium concentrations with glucose level and risk of diabetes mellitus: A cross sectional study of national health and nutrition examination survey, 1999-2006 [J].
Lin, Jingjing ;
Shen, Tao .
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2021, 63