Effects of Nicotine and Vagus Nerve in Severe Acute Pancreatitis-Associated Lung Injury in Rats

被引：17
作者：
Ma, Peng [1 ]
Yu, Kaihuan [1 ]
Yu, Jia [1 ]
Wang, Weixing [1 ]
Ding, Youming [1 ]
Chen, Chen [1 ]
Chen, Xiaoyan [1 ]
Zhao, Kailiang [1 ]
Zuo, Teng [1 ]
He, Xiaobo [1 ]
Shi, Qiao [1 ]
Ren, Jun [2 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Hepatobiliary & Laparoscop Surg, 238 Jiefang Rd, Wuhan 430060, Hubei Province, Peoples R China
[2] Hubei Univ Med, Affiliated Hosp, Dept Gen Surg, Xiangyang, Peoples R China
来源：
PANCREAS | 2016年 / 45卷 / 04期
基金：
中国国家自然科学基金;
关键词：
IL; -; interleukin; SAP - severe acute pancreatitis; MPO; myeloperoxidase; ELISA - enzyme-linked immunosorbent assay; HMGB1 - high-mobility group box 1; inflammation; TNF-alpha - tumor necrosis factor alpha; nicotine; LIPA; lipase; lung injury; vagotomy; alpha 7nAchR - alpha 7 nicotinic acetylcholine receptors; AMY; amylase; acute pancreatitis; CHOLINERGIC ANTIINFLAMMATORY PATHWAY; TUMOR-NECROSIS-FACTOR; MONOCLONAL-ANTIBODIES; ISCHEMIA-REPERFUSION; LETHAL BACTEREMIA; HEMORRHAGIC-SHOCK; ACTIVATION; STIMULATION; MICE; RECEPTORS;
D O I：
10.1097/MPA.0000000000000575
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Objectives The cholinergic anti-inflammatory pathway has been elucidated as a regulator of inflammatory responses in several experimental models of diseases. This regulatory mechanism is mediated by acetylcholine, released from efferent vagus nerve, interacts with alpha 7 nicotinic acetylcholine receptors on immune cells. Experimental evidence indicates that vagus nerve stimulation or alpha 7 nicotinic acetylcholine receptor agonists control proinflammatory cytokine production and protect animals in diverse lethal models. The aim of the study was to investigate effect of the cholinergic anti-inflammatory pathway in acute lung injury in an experimental model of severe acute pancreatitis (SAP). Methods In taurocholate-induced SAP in rats, pancreatitis was preceded by pretreatment with the nicotinic receptor agonist nicotine or unilateral left cervical vagotomy. Results Pretreatment with nicotine strongly alleviated severity of SAP-associated lung injury through attenuating serum amylase, lipase, and interleukin 6 levels; pancreas and lung pathological injury; lung myeloperoxidase activity; lung tumor necrosis factor-alpha; and high-mobility group box 1 expression. Inversely, vagotomy pretreatment resulted in an enhanced severity of pancreatitis and lung injury. Conclusions Our results reveal the role of the cholinergic anti-inflammatory pathway in experimental SAP-associated lung injury; nicotine pretreatment exerts a protective effect and vagotomy pretreatment exerts the opposite effect.
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收藏
页码：552 / 560
页数：9
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