Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders

被引：376
作者：
Brozovich, F. V. [2 ]
Nicholson, C. J. [1 ]
Degen, C. V. [3 ]
Gao, Yuan Z. [1 ]
Aggarwal, M. [1 ]
Morgan, K. G. [1 ]
机构：
[1] Boston Univ, Dept Hlth Sci, Boston, MA 02215 USA
[2] Mayo Clin, Dept Med, Rochester, MN USA
[3] Paracelsus Med Univ Salzburg, Salzburg, Austria
来源：
PHARMACOLOGICAL REVIEWS | 2016年 / 68卷 / 02期
关键词：
MYOSIN LIGHT-CHAIN; PROTEIN-KINASE-C; PULMONARY ARTERIAL-HYPERTENSION; ANGIOTENSIN-CONVERTING-ENZYME; GENOME-WIDE ASSOCIATION; PHOSPHATASE TARGET SUBUNIT; RHO-ASSOCIATED KINASE; TUMOR-NECROSIS-FACTOR; LONG NONCODING RNAS; HIGH BLOOD-PRESSURE;
D O I：
10.1124/pr.115.010652
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.
引用
收藏
页码：476 / 532
页数：57
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