Signaling from the oncogenic fusion protein BCR/ABL1 leads to expression of Wilms' tumor gene 1 protein (WT1), which induces transcriptional repression of interferon consensus sequence binding protein (ICSBP) in human cells.

被引:0
作者
Vidovic, Karina [1 ]
Svensson, Emelie [1 ]
Borg, Ake [1 ]
Vallon-Christersson, Johan [1 ]
Lassen, Carin [1 ]
Hakansson, Petra [1 ]
Richter, Johan [1 ]
Olofsson, Tor [1 ]
Fioretos, Thoas [1 ]
Gullberg, Urban [1 ]
Lindmark, Anders [1 ]
机构
[1] ILM, Lund, Sweden
关键词
D O I
10.1182/blood.V108.11.4322.4322
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
4322
引用
收藏
页码:159B / 159B
页数:1
相关论文
共 50 条
[21]   Role of interferon consensus sequence binding protein (ICSBP) in the regulation of tumor-induced CD11b+Gr1+myeloid suppressor cells [J].
Stewart, Trina J. ;
Greenelteh, Kristy ;
Schneider, Monika ;
Liu, Kebin ;
Abrams, Scott .
JOURNAL OF IMMUNOLOGY, 2006, 176 :S275-S275
[22]   The Wilms' tumour suppressor protein WT1 acts as a key transcriptional repressor of the human thromboxane A2 receptor gene in megakaryocytes [J].
Gannon, AnneMarie M. ;
Kinsella, B. Therese .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2009, 13 (11-12) :4571-4586
[24]   The Leukemia-associated Fusion Protein Tel-Platelet-derived Growth Factor Receptor β (Tel-PdgfRβ) Inhibits Transcriptional Repression of PTPN13 Gene by Interferon Consensus Sequence Binding Protein (Icsbp) [J].
Huang, Weiqi ;
Hu, Liping ;
Bei, Ling ;
Hjort, Elizabeth ;
Eklund, Elizabeth A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (11) :8110-8125
[25]   CHICKEN INTERFERON CONSENSUS SEQUENCE-BINDING PROTEIN (ICSBP) AND INTERFERON REGULATORY FACTOR (IRF)-1 GENES REVEAL EVOLUTIONARY CONSERVATION IN THE IRF GENE FAMILY [J].
JUNGWIRTH, C ;
REBBERT, M ;
OZATO, K ;
DEGEN, HJ ;
SCHULZ, U ;
DAWID, IB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3105-3109
[26]   In vitro treatment of chronic myeloid leukemia cells with STI571 leads to an equal reduction of Wilms tumor gene (WT1) and bcr/abl mRNA transcripts. [J].
Kreuzer, KA ;
Coutre, PI ;
Saborowski, A ;
Lupberger, J ;
Appelt, C ;
Na, IK ;
Bohn, A ;
Schmidt, CA .
BLOOD, 2000, 96 (11) :98A-99A
[27]   Transcriptional Repression of Tumor Suppressor CDC73, Encoding an RNA Polymerase II Interactor, by Wilms Tumor 1 Protein (WT1) Promotes Cell Proliferation IMPLICATION FOR CANCER THERAPEUTICS [J].
Rather, Mohammad Iqbal ;
Swamy, Shivananda ;
Gopinath, Kodaganur S. ;
Kumar, Arun .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (02) :968-976
[28]   Wilms’ tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells [J].
K Vidovic ;
E Svensson ;
B Nilsson ;
B Thuresson ;
T Olofsson ;
A Lennartsson ;
U Gullberg .
Leukemia, 2010, 24 :992-1000
[29]   Wilms' tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells [J].
Vidovic, K. ;
Svensson, E. ;
Nilsson, B. ;
Thuresson, B. ;
Olofsson, T. ;
Lennartsson, A. ;
Gullberg, U. .
LEUKEMIA, 2010, 24 (05) :992-1000
[30]   CpG DNA induces IL-12 p40 gene activation independent of STAT1 activation or production of interferon consensus sequence binding protein (ICSBP). [J].
Cowdery, JS ;
Schroeder, AJ ;
Morse, HC ;
Vogel, SN ;
Bradford, MA .
FASEB JOURNAL, 2002, 16 (04) :A322-A322