High-Throughput Automation in Chemical Process Development

被引：92
作者：
Selekman, Joshua A. [1 ]
Qiu, Jun [1 ]
Tran, Kristy [1 ]
Stevens, Jason [1 ]
Rosso, Victor [1 ]
Simmons, Eric [1 ]
Xiao, Yi [1 ]
Janey, Jacob [1 ]
机构：
[1] Bristol Myers Squibb Co, Chem & Synthet Dev, New Brunswick, NJ 08903 USA
来源：
ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 8 | 2017年 / 8卷
关键词：
laboratory automation; parallel experimentation; design of experiments; miniaturization; process optimization; PHARMACEUTICAL PROCESS-DEVELOPMENT; CHROMATOGRAPHIC-SEPARATIONS; ENZYMATIC-HYDROLYSIS; REACTION DISCOVERY; PALLADIUM REMOVAL; DRUG DISCOVERY; ION-EXCHANGE; OPTIMIZATION; DESIGN; CHEMISTRY;
D O I：
10.1146/annurev-chembioeng-060816-101411
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
High-throughput (HT) techniques built upon laboratory automation technology and coupled to statistical experimental design and parallel experimentation have enabled the acceleration of chemical process development across multiple industries. HT technologies are often applied to interrogate wide, often multidimensional experimental spaces to inform the design and optimization of any number of unit operations that chemical engineers use in process development. In this review, we outline the evolution of HT technology and provide a comprehensive overview of how HT automation is used throughout different industries, with a particular focus on chemical and pharmaceutical process development. In addition, we highlight the common strategies of how HT automation is incorporated into routine development activities to maximize its impact in various academic and industrial settings.
引用
收藏
页码：525 / 547
页数：23
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