Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort

被引:15
作者
Ebert, Helen [1 ]
Lacruz, Maria Elena [1 ]
Kluttig, Alexander [1 ]
Simm, Andreas [2 ,3 ]
Greiser, Karin Halina [1 ,4 ]
Tiller, Daniel [1 ]
Kartschmit, Nadja [1 ]
Mikolajczyk, Rafael [1 ]
机构
[1] Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol Biometr & Informat, Fac Med, Magdeburger Str 8, D-06112 Halle, Germany
[2] Univ Hosp Halle, Univ Clin, Middle German Heart Ctr, Halle, Germany
[3] Univ Hosp Halle, Outpatient Clin Cardiac Surg, Middle German Heart Ctr, Halle, Germany
[4] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany
关键词
Advanced glycosylation; Physical function; Biomarker; Disability; SERUM-LEVELS; RAGE; PATHOGENESIS; HEALTH; AGES; ENDPRODUCTS; MORTALITY; BIOMARKER; PROTEIN; RISK;
D O I
10.1186/s12877-019-1323-8
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent studies suggested that the ratio of AGEs and their soluble receptor (sRAGE) is a more accurate biomarker for age-related diseases than each separately. We aim to investigate whether this also applies for physical functioning in a broad age-spectrum. Methods AGE and sRAGE levels, and physical functioning (SF-12 questionnaire) of 967 men and 812 women (45-83 years) were measured in the CARLA study. We used ordinal logistic regression to examine associations between AGEs, sRAGE, and AGE/sRAGE ratio with physical functioning in sex- and age-stratified models. Results Higher levels of AGEs and AGE/sRAGE ratio were associated with lower physical functioning only in women, even after consideration of classical lifestyle and age-related factors (education, BMI, smoking, alcohol consumption, diet, creatinine clearance, diabetes mellitus, lipid lowering and antihypertensive drugs) (odds ratio (OR) =0.86, 95%confidence interval = 0.74-0.98 and OR = 0.86, 95%CI = 0.75-0.98 for AGEs and AGE/sRAGE ratio respectively). We could not demonstrate a significant difference across age. Conclusions We showed a sex-specific association between physical functioning and AGEs and AGE/sRAGE, but no stronger associations of the latter with physical functioning. Further investigation is needed in the pathophysiology of this association.
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页数:8
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